Search Clinical Trials
Sponsor Condition of Interest |
---|
Video Telehealth Exercise Training in Cystic Fibrosis
University of Alabama at Birmingham
Cystic Fibrosis
The purpose of this research study is to begin an exercise program for patients with a
cystic fibrosis (CF) exacerbation. expand
The purpose of this research study is to begin an exercise program for patients with a cystic fibrosis (CF) exacerbation. Type: Interventional Start Date: Jul 2022 |
Molecular Residual Disease (MRD) Guided Adjuvant ThErapy in Renal Cell Carcinoma (RCC)
University of Alabama at Birmingham
Renal Cell Carcinoma
The goal of this Clinical Study is to understand the outcomes by informing therapy choice
for adjuvant treatment in clear cell renal cell carcinoma by using molecular residual
disease.
The main question[s] it aims to answer are:
- what is the progression free survival of a cohort of high risk... expand
The goal of this Clinical Study is to understand the outcomes by informing therapy choice for adjuvant treatment in clear cell renal cell carcinoma by using molecular residual disease. The main question[s] it aims to answer are: - what is the progression free survival of a cohort of high risk resected RCC patients when treated based on MRD - what is the overall survival of high risk resected RCC patients when treated based on MRD Participants will forgo adjuvant therapy with pembrolizumab if they have no detectable molecular residual disease. Participants will continue on with standard of care pembrolizumab if they do appear to have molecular residual disease. Type: Interventional Start Date: Dec 2023 |
Positron Emission Tomography (PET) Imaging of Neuroinflammation in Patients With Neurological Dysfunction...
University of Alabama at Birmingham
SARS CoV-2 Post-Acute Sequelae
This clinical imaging study will use the small molecule translocator protein (TSPO)
ligand, Fluorodeoxyglucose(18F)-labeled DPA-714, to visualize and quantify
neuroinflammation in individuals with post-acute sequelae of SARS-CoV-2 (PASC) . The
brain uptake of DPA-714 will be contrasted with healthy... expand
This clinical imaging study will use the small molecule translocator protein (TSPO) ligand, Fluorodeoxyglucose(18F)-labeled DPA-714, to visualize and quantify neuroinflammation in individuals with post-acute sequelae of SARS-CoV-2 (PASC) . The brain uptake of DPA-714 will be contrasted with healthy subjects. Type: Interventional Start Date: Nov 2023 |
Executive Functioning Training Study
University of Alabama at Birmingham
Aging
Cognitive Function Abnormal
Cognitive Performance
Cognitive Training
Older Adults
Cognitive aging in people with HIV (PWH) is of increasing concern for several reasons: 1)
between 52%-59% of PWH experience cognitive impairment known as HIV-Associated
Neurocognitive Disorder (HAND) which impacts everyday functioning and quality of life; 2)
HAND increases in severity and prevalence... expand
Cognitive aging in people with HIV (PWH) is of increasing concern for several reasons: 1) between 52%-59% of PWH experience cognitive impairment known as HIV-Associated Neurocognitive Disorder (HAND) which impacts everyday functioning and quality of life; 2) HAND increases in severity and prevalence with age; and 3) 70% of PWH in the United States will be 50 and older by 2030. Fortunately, cognitive training programs can individually target specific cognitive impairments in PWH and possibly reduce the severity and prevalence of HAND and improve everyday functioning and quality of life. This approach is based around the underlying concept of intra-individual variability as controlled through higher level allocation of cognitive resources, known as executive functioning. This feasibility study will use a two-group pre-post experimental design of adults with HAND including: 1) a 20-hours of Executive Functioning Training group (enroll 60, n=48 with attrition), and 2) a no-contact control (enroll 60, n=48 with attrition). Aim 1 - Feasibility: To determine feasibility and acceptability of the intervention (i.e., attrition, feedback). Exploratory Aim 1 - Cognition: Compare adults who receive Executive Functioning Training to those who receive no training to determine whether they improve in global cognitive ability and overall cognitive IIV. This high impact study is innovative in the following ways: 1) This is the first study aimed to reduce cognitive IIV in PWH. 2) This is the first study to use IIV as a guide to target solely executive functioning training to improve global cognitive ability, which may reduce the severity and prevalence of HAND. 3) Over the last decade, the epicenter of HIV has emerged in the Deep South where this study will occur. Most participants in this study will be older PWH who identify as lower social economic status (SES) and/or African Americans and experience HAND symptoms. Type: Interventional Start Date: Jun 2023 |
Intravesical BCG vs GEMDOCE in NMIBC
ECOG-ACRIN Cancer Research Group
Non-muscle-invasive Bladder Cancer
The study hypothesis is that BCG naïve non-muscle invasive bladder cancer (NMIBC)
patients treated with intravesical Gemcitabine + Docetaxel (GEMDOCE) will result in a
non-inferior event-free survival (EFS) compared to standard treatment with intravesical
BCG. The purpose of this study is to test... expand
The study hypothesis is that BCG naïve non-muscle invasive bladder cancer (NMIBC) patients treated with intravesical Gemcitabine + Docetaxel (GEMDOCE) will result in a non-inferior event-free survival (EFS) compared to standard treatment with intravesical BCG. The purpose of this study is to test whether Gemcitabine + Docetaxel is a better or worse treatment than the usual BCG therapy approach. The primary objective of this study is to determine the event free survival (EFS) of BCG-naïve high grade non-muscle invasive bladder cancer patients treated with intravesical BCG vs Gemcitabine + Docetaxel. Secondary objectives are as follows: to compare changes in cancer-specific and bladder cancer-specific QOL from baseline to treatment between BCG-naïve high grade NMIBC patients receiving BCG and GEMDOCE, to determine the cystectomy free survival (CFS) of BCG-naïve high grade NMIBC patients treated with intravesical BCG vs GEMDOCE, to determine the progression free survival (PFS) of BCG-naïve high grade NMIBC patients treated with intravesical BCG vs GEMDOCE, and to determine the safety and toxicity of BCG-naïve high grade NMIBC patients treated with intravesical BCG vs GEMDOCE. Type: Interventional Start Date: Feb 2023 |
Neuroinflammation in Asymptomatic Carotid Artery Disease - Imaging Substudy
University of Alabama at Birmingham
Critical Asymptomatic Carotid Artery Disease
Non-Critical Asymptomatic Carotid Artery Disease
This clinical imaging substudy will use the small molecule translocator protein (TSPO)
ligand, Fludeoxyglucose(18F)-labeled DPA-714, to compare neuroinflammation in individuals
with high or low grade asymptomatic carotid artery stenosis (aCAD) who are participating
in the separate Neuroinflammation... expand
This clinical imaging substudy will use the small molecule translocator protein (TSPO) ligand, Fludeoxyglucose(18F)-labeled DPA-714, to compare neuroinflammation in individuals with high or low grade asymptomatic carotid artery stenosis (aCAD) who are participating in the separate Neuroinflammation in Asymptomatic Carotid Artery Disease study lead by Dr. Ron Lazar (IRB-300007806). The positron emission tomography (PET) tracer [18F]DPA-714 binds to the 18 kDa translocator protein (TSPO, also known as the peripheral benzodiazepine receptor) in the mitochondria of activated microglia/macrophages and provides a non-invasive measure of neuroinflammation. Type: Interventional Start Date: Apr 2025 |
Sequential Therapy in Multiple Myeloma Guided by MRD Assessments
University of Alabama at Birmingham
Multiple Myeloma
This research study will determine the proportion of patients with lowest minimal
residual disease (MRD) response obtainable after receiving 6 cycles of study treatment.
Minimal residual disease is multiple myeloma cells below the level of 1 cancer cell out
of 100,000 in the bone marrow.
For patients... expand
This research study will determine the proportion of patients with lowest minimal residual disease (MRD) response obtainable after receiving 6 cycles of study treatment. Minimal residual disease is multiple myeloma cells below the level of 1 cancer cell out of 100,000 in the bone marrow. For patients who become MRD "negative" (i.e. less than 1 cancer cell out of 100,000) at the end of 6 cycles of therapy, this study will study if that good response can be maintained with 3 additional cycles of treatment instead of use of autologous hematopoietic cell transplantation (AHCT). For patients who are MRD "positive" at the end of 6 cycles of therapy, this study will answer whether more patients can become and remain MRD "negative" with AHCT plus teclistamab in combination with daratumumab when compared with patients who undergo AHCT followed by lenalidomide (an established anti-myeloma drug) plus daratumumab. Type: Interventional Start Date: Dec 2023 |
Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH)
Johns Hopkins University
Intracerebral Hemorrhage
This first-in-patient phase 2a pilot study will assess the safety and tolerability of
MW01-6-189WH (hereafter called MW189) in patients with Intracerebral Hemorrhage (ICH). expand
This first-in-patient phase 2a pilot study will assess the safety and tolerability of MW01-6-189WH (hereafter called MW189) in patients with Intracerebral Hemorrhage (ICH). Type: Interventional Start Date: Oct 2022 |
Decision Support Training for Advanced Cancer Family Caregivers: The CASCADE Factorial Trial
University of Alabama at Birmingham
Family Members
Cancer
Using a highly innovative methodology, the Multiphase Optimization Strategy (MOST), the
purpose of this randomized factorial trial is to identify components of a intervention
(CASCADE) to enhance the decision support skills of family caregivers of persons with
newly-diagnosed advanced cancer. Using... expand
Using a highly innovative methodology, the Multiphase Optimization Strategy (MOST), the purpose of this randomized factorial trial is to identify components of a intervention (CASCADE) to enhance the decision support skills of family caregivers of persons with newly-diagnosed advanced cancer. Using a 2x2x2x2 full factorial design, 352 family caregivers of persons with newly-diagnosed advanced cancer will be randomized to receive one or more nurse coach-delivered decision partnering training components, based on the Ottawa Decision Support Framework and Social Support Effectiveness Theory: 1) psychoeducation on effective decision partnering principles (1 vs. 3 sessions); 2) decision partnering communication training (yes vs. no); 3) Ottawa Decision Guide training (yes vs. no); and monthly follow (1 monthly follow-up call vs. monthly follow-up calls for 24 weeks). Type: Interventional Start Date: Jan 2022 |
Gout in the ED and Improving Research Participation
University of Alabama at Birmingham
Gout
The prevalence of gout has been steadily increasing over several decades and is
correlated with the rising burden of obesity, chronic cardiac and renal disease; all
conditions overrepresented in the Southeastern U.S. - particularly in African Americans.
Through a novel emergency department led intervention... expand
The prevalence of gout has been steadily increasing over several decades and is correlated with the rising burden of obesity, chronic cardiac and renal disease; all conditions overrepresented in the Southeastern U.S. - particularly in African Americans. Through a novel emergency department led intervention we aim to improve the care patients with gout receive, both during acute exacerbations and long-term. A secondary goal of the project is to concurrently enhance participation of minorities in biomedical research in the Deep South. Type: Interventional Start Date: Jun 2021 |
Feasibility of a New Model for Exercise Prescription in Cystic Fibrosis
University of Alabama at Birmingham
Cystic Fibrosis
The purpose of this protocol is to begin an exercise program combined with behavioral
counseling for patients who are hospitalized with a cystic fibrosis exacerbation. The
exercise program will begin during the hospital stay. Beginning an exercise program
during this period of reduced mobility and... expand
The purpose of this protocol is to begin an exercise program combined with behavioral counseling for patients who are hospitalized with a cystic fibrosis exacerbation. The exercise program will begin during the hospital stay. Beginning an exercise program during this period of reduced mobility and isolation may be an ideal time to deliver a structured exercise prescription along with a behavioral program to promote long-term adherence to exercise (structured physical activity) . Hospitalized patients have an acute awareness that their lung function is declining and may be more motivated and open to changing their behavior and adding exercise to their treatment regimen. Type: Interventional Start Date: Dec 2020 |
Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD
University of Alabama at Birmingham
Parkinson Disease
The purpose of the study is to determine whether new deep brain stimulation (DBS) device
technologies can generate and record brain rhythms to reveal the best location for
clinical stimulation. expand
The purpose of the study is to determine whether new deep brain stimulation (DBS) device technologies can generate and record brain rhythms to reveal the best location for clinical stimulation. Type: Interventional Start Date: Jan 2024 |
Cabozantinib and Dostarlimab in Recurrent Gynecologic Carcinosarcoma
University of Alabama at Birmingham
Gynecologic Cancer
Carcinoma
Uterine Cancer
Endometrial Cancer
Immunotherapy has gained a significant amount of attention recently, but its efficacy as
a single agent in gynecological cancers has been disappointing. Pre-clinical evidence
supports the combination of using Vascular Endothelial Growth Factors (VEGF) inhibitors
with immunotherapy. VEGF inhibitors... expand
Immunotherapy has gained a significant amount of attention recently, but its efficacy as a single agent in gynecological cancers has been disappointing. Pre-clinical evidence supports the combination of using Vascular Endothelial Growth Factors (VEGF) inhibitors with immunotherapy. VEGF inhibitors suppress the activation of tumor-associated macrophages (TAMs) and VEGF has been shown to affect the functional maturation of dendritic cells; therefore, VEGF inhibitors could improve the function of antigen presentation. In this study, Cabozantinib (VEGF inhibitor) and Dostarlimab (immunotherapeutic drug) will be admnistered as a combination to patients with recurrent gynecologic carcinosarcoma. Type: Interventional Start Date: Aug 2023 |
Azithromycin Treatment for Respiratory Syncytial Virus-induced Respiratory Failure in Children
University of Alabama at Birmingham
Respiratory Syncytial Virus Infections
The overarching hypothesis of the ARRC trial is that administration of Azithromycin (AZM)
during acute, Respiratory Syncytial Virus (RSV)-induced respiratory failure will be
beneficial, mediated through the matrix metalloproteinase (MMP)-9 pathway. expand
The overarching hypothesis of the ARRC trial is that administration of Azithromycin (AZM) during acute, Respiratory Syncytial Virus (RSV)-induced respiratory failure will be beneficial, mediated through the matrix metalloproteinase (MMP)-9 pathway. Type: Interventional Start Date: Feb 2022 |
Effect of Preoperative Mobility Device Training on Postoperative Fall Incidence
University of Alabama at Birmingham
Injury; Muscle, Ankle, and Foot, Multiple
The purpose of this study is to determine whether preoperative mobility device training
is beneficial in reducing incidence of postoperative falls in patients undergoing
elective foot and ankle surgery requiring a postoperative period of no weight-bearing. expand
The purpose of this study is to determine whether preoperative mobility device training is beneficial in reducing incidence of postoperative falls in patients undergoing elective foot and ankle surgery requiring a postoperative period of no weight-bearing. Type: Interventional Start Date: Sep 2019 |
Autism Spectrum Disorder (ASD) and Intellectual Disability (ID) Determinants in Tuberous Sclerosis Complex...
Boston Children's Hospital
Tuberous Sclerosis
Autism Disorder
Intellectual Disability
The purpose of this study is to characterize the developmental phenotype of ASD and ID
and to identify biomarkers using advanced MRI methodology and electrophysiological
biomarkers of synaptic function and connectivity predictive of ASD and ID presence and
severity in patients with TSC. In addition,... expand
The purpose of this study is to characterize the developmental phenotype of ASD and ID and to identify biomarkers using advanced MRI methodology and electrophysiological biomarkers of synaptic function and connectivity predictive of ASD and ID presence and severity in patients with TSC. In addition, this study will be establishing infrastructure for the collection and storage of human bio-specimens, including genetic material, from TSC patients and their family members with ASD. Type: Observational Start Date: May 2015 |
A Single-arm, Multicenter Study to Assess the Efficacy, Safety, and Tolerability of P1101 in Adults With...
PharmaEssentia
Essential Thrombocythemia
A Single-arm, Multicenter Study to Assess the Efficacy, Safety, and Tolerability of
Ropeginterferon alfa-2b-njft (P1101) in Adult Patients with Essential Thrombocythemia expand
A Single-arm, Multicenter Study to Assess the Efficacy, Safety, and Tolerability of Ropeginterferon alfa-2b-njft (P1101) in Adult Patients with Essential Thrombocythemia Type: Interventional Start Date: Sep 2022 |
Multi-Center African-American Inflammatory Bowel Disease Study (MAAIS)
Johns Hopkins University
Inflammatory Bowel Disease
The investigators are doing the research to discover genes that cause Inflammatory Bowel
Disease (IBD) specifically in the African American population. African Americans with or
without Crohn's disease or ulcerative colitis are eligible to join. If you agree to join
the study, the investigators will... expand
The investigators are doing the research to discover genes that cause Inflammatory Bowel Disease (IBD) specifically in the African American population. African Americans with or without Crohn's disease or ulcerative colitis are eligible to join. If you agree to join the study, the investigators will ask for information about your health. The investigators will also ask you to give us a blood sample so that they may discover the genes that cause IBD. The blood sample may be collected at Johns Hopkins or any local facility convenient to you. Type: Observational Start Date: Jun 2003 |
Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients...
Celcuity Inc
Breast Cancer
This is a Phase 3, open-label, randomized, clinical trial evaluating the efficacy and
safety of gedatolisib plus fulvestrant with or without palbociclib for the treatment of
patients with locally advanced or metastatic HR+/HER2- breast cancer following
progression on or after CDK4/6 and aromatase... expand
This is a Phase 3, open-label, randomized, clinical trial evaluating the efficacy and safety of gedatolisib plus fulvestrant with or without palbociclib for the treatment of patients with locally advanced or metastatic HR+/HER2- breast cancer following progression on or after CDK4/6 and aromatase inhibitor therapy. Type: Interventional Start Date: Sep 2022 |
Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection
University of Calgary
Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection
Hemolytic-Uremic Syndrome
The objective of this study is to determine if early high volume intravenous fluid
administration (hyperhydration) may be effective in mitigating or preventing
complications of shiga toxin-producing E. coli (STEC) infection in children and
adolescents when compared with traditional approaches (conservative... expand
The objective of this study is to determine if early high volume intravenous fluid administration (hyperhydration) may be effective in mitigating or preventing complications of shiga toxin-producing E. coli (STEC) infection in children and adolescents when compared with traditional approaches (conservative fluid management). Type: Interventional Start Date: Sep 2022 |
DMSO Cryopreserved Platelets in Cardiopulmonary Bypass Surgery (CRYPTICS)
Cellphire Therapeutics, Inc.
Cardiac Surgery
A randomized, parallel group, active comparator-controlled trial to evaluate the
non-inferiority or superiority of Cryopreserved Platelets with Liquid Stored Platelets in
controlling blood loss in patients undergoing Cardiopulmonary Bypass Surgery. expand
A randomized, parallel group, active comparator-controlled trial to evaluate the non-inferiority or superiority of Cryopreserved Platelets with Liquid Stored Platelets in controlling blood loss in patients undergoing Cardiopulmonary Bypass Surgery. Type: Interventional Start Date: Sep 2021 |
Follow-up Visit of High Risk Infants
NICHD Neonatal Research Network
Infant, Newborn
Infant, Low Birth Weight
Infant, Small for Gestational Age
Infant, Premature
The NICHD Neonatal Research Network's Follow-Up study is a multi-center cohort in which
surviving extremely low birth-weight infants born in participating network centers
receive neurodevelopmental, neurosensory and functional assessments at 22-26 months
corrected age (Infants born prior to July 1,... expand
The NICHD Neonatal Research Network's Follow-Up study is a multi-center cohort in which surviving extremely low birth-weight infants born in participating network centers receive neurodevelopmental, neurosensory and functional assessments at 22-26 months corrected age (Infants born prior to July 1, 2012 were seen at 18-22 months corrected age). Data regarding pregnancy and neonatal outcome are collected prospectively. The goal is to identify potential maternal and neonatal risk factors that may affect infant neurodevelopment. Type: Observational Start Date: Jan 1993 |
ACT NOW Longitudinal Study: Outcomes of Babies With Opioid Exposure Study
Advancing Clinical Trials in Neonatal Opioid Withdrawal (ACT NOW) Program
Neonatal Opioid Withdrawal Syndrome
The objective of this longitudinal cohort study is to quantify the effects of antenatal
opioid exposure on the trajectory of brain development over the first 2 years of life,
examine associations with developmental and neurobehavioral outcomes, and explore how
specific factors (differing antenatal... expand
The objective of this longitudinal cohort study is to quantify the effects of antenatal opioid exposure on the trajectory of brain development over the first 2 years of life, examine associations with developmental and neurobehavioral outcomes, and explore how specific factors (differing antenatal and postnatal exposures, severity of neonatal opioid withdrawal, maternal stress/depression/parenting) modify these effects Type: Observational Start Date: Aug 2020 |
HCRN Core Data Project: Characterizing Patient Populations in the Hydrocephalus Clinical Research Network...
University of Utah
Pediatric Hydrocephalus
The Hydrocephalus Clinical Research Network (HCRN) has been established by philanthropic
funding to conduct multi-institutional research (clinical trials and observational
studies) on pediatric hydrocephalus. In addition to philanthropic funding, the HCRN has
also received an NIH NINDS Challenge Grant... expand
The Hydrocephalus Clinical Research Network (HCRN) has been established by philanthropic funding to conduct multi-institutional research (clinical trials and observational studies) on pediatric hydrocephalus. In addition to philanthropic funding, the HCRN has also received an NIH NINDS Challenge Grant to support the network infrastructure which allows for the conduct of this and other network studies. The HCRN consists of multiple Clinical Centers and the Data Coordinating Center (DCC). The HCRN Core Data Project will obtain data about all neurosurgical hydrocephalus events from the network Clinical Centers, and create a database to be used by HCRN investigators. The ongoing maintenance of the Core Data Project serves two main purposes: 1) it will help investigators understand the variability, progression, and current treatment practices for hydrocephalus in children, with an ultimate goal of better guiding and assessing therapeutic intervention and providing recommendations on patient care and, 2) it will provide pilot and descriptive data necessary for hypothesis generation and study design (i.e. preliminary power analyses, recruitment projections) for studies under development by the HCRN. This multi-institutional database will be maintained throughout the lifetime of the HCRN, and may be useful for tracking trends in pediatric hydrocephalus over time. The Core Data Project will be an invaluable resource to the HCRN and will help stimulate new research protocols, identify potential need for future expansion of the network to incorporate additional patient populations, and provide a descriptive understanding of children with hydrocephalus cared for within the network. Type: Observational Start Date: Apr 2008 |
The EndRAD Trial: Eliminating Total Body Irradiation (TBI) for NGS-MRD Negative Children, Adolescents,...
Children's Hospital Los Angeles
B-cell Acute Lymphoblastic Leukemia
This study will evaluate the use of non- TBI (total body irradiation) conditioning for
B-ALL patients with low risk of relapse as defined by absence of NGS-MRD (next generation
sequencing minimal residual disease) before receiving a hematopoietic cell transplant
(HCT). Patients diagnosed with B-ALL... expand
This study will evaluate the use of non- TBI (total body irradiation) conditioning for B-ALL patients with low risk of relapse as defined by absence of NGS-MRD (next generation sequencing minimal residual disease) before receiving a hematopoietic cell transplant (HCT). Patients diagnosed with B-ALL who are candidates for HCT will be screened by NGS-MRD on a test of bone marrow done before the HCT. Subjects who are pre-HCT NGS-MRD negative will be eligible to receive a non-TBI conditioning regimen as part of the treatment cohort of the study. Subjects who are pre-HCT NGS-MRD positive will be treated as per treating center standard and will be followed in an observational cohort (HCT center standard of care). Type: Interventional Start Date: Aug 2018 |
- Previous
- Next