
Search Clinical Trials
Study is registered in ResearchMatch ![]() Sponsor Condition of Interest |
---|
Feasibility of the First Known Adaptive Intervention for People With SCI
![]()
University of Alabama at Birmingham
Spinal Cord Injuries
The overall goal of the proposed research is to conduct a pilot study to test the feasibility
and acceptability of a home-based exercise intervention (SMART-HEALTH). The primary purpose
of the pilot study is to assess the feasibility of intervention delivery (Aim 1), the
acceptability... expand
The overall goal of the proposed research is to conduct a pilot study to test the feasibility and acceptability of a home-based exercise intervention (SMART-HEALTH). The primary purpose of the pilot study is to assess the feasibility of intervention delivery (Aim 1), the acceptability of the intervention by participants (Aim 2) and estimate effect sizes for a future trial (Aim 3). Type: Interventional Start Date: Jun 2022 |
A Trial of Bardoxolone Methyl in Patients With ADPKD - FALCON
![]()
Reata Pharmaceuticals, Inc.
Autosomal Dominant Polycystic Kidney
ADPKD
This international, multi-center, randomized, double-blind, placebo-controlled Phase 3 trial
will study the safety, tolerability, and efficacy of bardoxolone methyl in qualified patients
with ADPKD. Approximately 850 patients will be enrolled.
expand
This international, multi-center, randomized, double-blind, placebo-controlled Phase 3 trial will study the safety, tolerability, and efficacy of bardoxolone methyl in qualified patients with ADPKD. Approximately 850 patients will be enrolled. Type: Interventional Start Date: May 2019 |
Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3) Protocol
![]()
University of Southern California
Mild Cognitive Impairment (MCI)
Alzheimer's Disease (AD)
Since its launch in 2004, the overarching aim of the Alzheimer's Disease Neuroimaging
Initiative (ADNI) has been realized in informing the design of therapeutic trials in AD.
ADNI3 continues the previously funded ADNI-1, ADNI-GO, and ADNI-2 studies that have been
combined... expand
Since its launch in 2004, the overarching aim of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has been realized in informing the design of therapeutic trials in AD. ADNI3 continues the previously funded ADNI-1, ADNI-GO, and ADNI-2 studies that have been combined public/private collaborations between academia and industry to determine the relationships between the clinical, cognitive, imaging, genetic and biochemical biomarker characteristics of the entire spectrum of Alzheimer's disease (AD). The overall goal of the study is to continue to discover, optimize, standardize, and validate clinical trial measures and biomarkers used in AD research. Type: Observational Start Date: Oct 2016 |
Improving Thinking in Everyday Life After Covid-19
![]()
University of Alabama at Birmingham
Covid-19
Cognitive Impairment
The purpose of this initial study is to evaluate a new form of cognitive rehabilitation
therapy for improving your ability to think, particularly how rapidly you process information
that you receive from your senses, e.g., sight, hearing, and smell. The study will also test... expand
The purpose of this initial study is to evaluate a new form of cognitive rehabilitation therapy for improving your ability to think, particularly how rapidly you process information that you receive from your senses, e.g., sight, hearing, and smell. The study will also test how often and how well you carry out tasks that rely on thinking in your daily life. You will be randomly assigned to receive the new therapy soon or about three months later. In other words, your treatment schedule will be determined by chance. The new therapy involves intensive, repetitive cognitive exercises (up to 3.5hr/day for 10 consecutive weekdays) with rest periods interspersed as needed. Type: Interventional Start Date: Nov 2020 |
Evaluating the Safety and Immunogenicity of EnvSeq-1 and CH505 M5 gp120 Envs Adjuvanted With GLA-SE in...
![]()
National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
The purpose of this study is to evaluate the safety, tolerability, and immunogenicity of
EnvSeq-1 and CH505 M5 gp120 Envs adjuvanted with GLA-SE in healthy, HIV-uninfected adults.
expand
The purpose of this study is to evaluate the safety, tolerability, and immunogenicity of EnvSeq-1 and CH505 M5 gp120 Envs adjuvanted with GLA-SE in healthy, HIV-uninfected adults. Type: Interventional Start Date: Aug 2017 |
Using Interactive Virtual Presence to Remotely Assist Parents With Child Restraint Installations
![]()
University of Alabama at Birmingham
Car Seat Installation
Motor vehicle crashes cause the death of an American child every 3 hours, more than any other
cause. When installed correctly, car seats reduce risk of serious injury and death to infants
and young children. Unfortunately, a large portion of child restraints is installed
incorrectly.... expand
Motor vehicle crashes cause the death of an American child every 3 hours, more than any other cause. When installed correctly, car seats reduce risk of serious injury and death to infants and young children. Unfortunately, a large portion of child restraints is installed incorrectly. A network of trained technicians work across the country to assist parents in achieving correct use of child restraints through scheduled "car seat checks," where technicians work with parents to install restraints in their vehicles. Car seat checks are effective in reducing errors in child restraint installations. However, the services are highly underutilized. The present study evaluates use of interactive virtual presence technology (also called interactive merged reality) to remotely assist parents to install child restraints correctly into their vehicles. Building from small pilot studies on the topic, the investigators will conduct a randomized non-inferiority trial to evaluate whether parents who install child restraints while communicating with a remote expert technician via interactive virtual presence achieve installations and learning that are not inferior in their safety to parents who install restraints live with a remote technician onsite. The investigators will recruit 1476 parents at 7 locations nationwide and randomly assign consenting parents to install their child restraint either via interactive virtual presence or with a live technician. The correctness of installation safety will be assessed using objective checklists, both following installation and again four months later. The investigators aim to demonstrate that child restraint installation is accurate (>90% correct) when conducted remotely via interactive virtual presence, that such installations are not inferior to the accuracy of installation with a live on-site expert, and that parents learn and retain information about correct child restraint installation. Type: Interventional Start Date: Jan 2020 |
Circadian Mechanisms Underlying Non-Dipping Blood Pressure in Blacks
![]()
University of Alabama at Birmingham
Circadian Rhythm
Blood Pressure
This study seeks to examine central and peripheral circadian mechanisms in Blacks with
appropriately dipping systolic blood pressure (blood pressure that dips by at least 10%)
compared with non-dipping systolic blood pressure (blood pressure that dips by less than 10%)
using... expand
This study seeks to examine central and peripheral circadian mechanisms in Blacks with appropriately dipping systolic blood pressure (blood pressure that dips by at least 10%) compared with non-dipping systolic blood pressure (blood pressure that dips by less than 10%) using a constant routine protocol. Constant routine protocols are commonly used in the field of circadian biology to examine rhythms in biological processes while controlling the entraining effects of light, activity, and diet. Type: Interventional Start Date: Jan 2020 |
Doravirine for Persons With Excessive Weight Gain on Integrase Inhibitors and Tenofovir Alafenamide
![]()
AIDS Clinical Trials Group
HIV Infections
The primary purpose of this study is to see if people with HIV who had a significant weight
gain after starting INSTI (integrase strand transfer inhibitor)+TAF/FTC (tenofovir
alafenamide/emtricitabine) (TAF/3TC (lamivudine)) regimen could either slow their rate of
weight gain... expand
The primary purpose of this study is to see if people with HIV who had a significant weight gain after starting INSTI (integrase strand transfer inhibitor)+TAF/FTC (tenofovir alafenamide/emtricitabine) (TAF/3TC (lamivudine)) regimen could either slow their rate of weight gain or lose weight within about 1 year if they switch to a regimen containing doravirine (DOR; a newer, non-nucleoside reverse transcriptase inhibitor medication). The study will also try to see if participants changing from TAF/FTC (or TAF/3TC) to TDF/FTC (or TDF/3TC) will experience less additional weight gain or a reduction in overall body weight at 48 weeks compared to persons continued on an INSTI + TAF/FTC (or TAF/3TC) combination. INSTINs assessed in A5391 include bictegravir (BIC), dolutegravir (DTG), or raltegravir (RAL). Additionally, the study will see whether a change in ART can affect things like waist circumference, metabolic and cardiovascular health, fat and lean mass body composition, bone health, and maintenance of virologic suppression. Finally, the study will look at the safety and tolerability of DOR plus either TAF/FTC (or TAF/3TC) versus TDF/FTC (or TDF/3TC). Type: Interventional Start Date: May 2021 |
Transcranial Direct Current Stimulation for Post-stroke Motor Recovery
![]()
Duke University
Stroke, Ischemic
Motor Activity
Upper Extremity Paralysis
This research study is to find out if brain stimulation at different dosage level combined
with an efficacy-proven rehabilitation therapy can improve arm function. The stimulation
technique is called transcranial direct current stimulation (tDCS). The treatment uses direct... expand
This research study is to find out if brain stimulation at different dosage level combined with an efficacy-proven rehabilitation therapy can improve arm function. The stimulation technique is called transcranial direct current stimulation (tDCS). The treatment uses direct currents to stimulate specific parts of the brain affected by stroke. The adjunctive rehabilitation therapy is called "modified Constraint-Induced Movement Therapy" (mCIMT). During this therapy the subject will wear a mitt on the hand of the arm that was not affected by a stroke and force to use the weak arm. The study will test 3 different doses of brain stimulation in combination with mCIMT to find out the most promising one. Type: Interventional Start Date: Sep 2019 |
Study to Assess the Effectiveness and Safety of Lenacapavir for Human Immunodeficiency Virus (HIV) Pre-Exposure...
![]()
Gilead Sciences
Pre-Exposure Prophylaxis of HIV Infection
The primary objective of this study is to evaluate the efficacy of lenacapavir (LEN) in
preventing the risk of human immunodeficiency virus (HIV) - 1 infection relative to the
background HIV-1 incidence rate.
The study will be conducted in 2 parts: a cross-sectional study... expand
The primary objective of this study is to evaluate the efficacy of lenacapavir (LEN) in preventing the risk of human immunodeficiency virus (HIV) - 1 infection relative to the background HIV-1 incidence rate. The study will be conducted in 2 parts: a cross-sectional study (Incidence Phase) and a double-blind, randomized study (Randomized Phase). The Incidence Phase will include initial assessments that will provide an estimate of the concurrent background HIV-1 incidence rate. The Randomized Phase of the study will have a Blinded Phase, a LEN Open-label Extension (OLE) Phase, and a pharmacokinetic (PK) Tail Phase. The primary objective for the Incidence Phase of this study is to estimate the HIV-1 background incidence rate. The primary objective of the Randomized Blinded Phase of this study is to evaluate the efficacy of lenacapavir for HIV-1 pre-exposure prophylaxis (PrEP) in cisgender men (CGM), transgender women (TGW), transgender men (TGM), and gender nonbinary people (GNB) ≥ 16 years of age who have condomless receptive anal sex with partners assigned male at birth and are at risk for HIV-1 infection. Type: Interventional Start Date: Jun 2021 |
A Prospective Comparative Study of Outcomes With Proton and Photon Radiation in Prostate Cancer
![]()
University of Florida
Prostate Cancer
This study is a large, prospective, pragmatic, controlled comparison of patient-centric
outcomes [quality of life (QOL), toxicity, and disease control] between parallel cohorts of
men with prostate cancer treated simultaneously at proton therapy facilities and at
geographically... expand
This study is a large, prospective, pragmatic, controlled comparison of patient-centric outcomes [quality of life (QOL), toxicity, and disease control] between parallel cohorts of men with prostate cancer treated simultaneously at proton therapy facilities and at geographically similar conventional (photon-based) radiation facilities using intensity-modulated radiation therapy (IMRT) techniques. Type: Interventional Start Date: Jul 2018 |
Sling vs Botox for Mixed Incontinence
![]()
NICHD Pelvic Floor Disorders Network
Urinary Incontinence, Stress
Urinary Incontinence, Urge
The primary aim is to compare the effectiveness of intradetrusor injection of 100 unit
injection of Botulinum toxin A to mid-urethral sling for change in MUI symptoms 6 months
following treatment.
expand
The primary aim is to compare the effectiveness of intradetrusor injection of 100 unit injection of Botulinum toxin A to mid-urethral sling for change in MUI symptoms 6 months following treatment. Type: Interventional Start Date: Jul 2020 |
An Extension Study for Participants Who Have Completed the Treatment Period of a Qualifying Parent Study
Pfizer
Dermatomyositis
The purpose of this research study is to evaluate the long-term safety, and tolerability of
PF-06823859 study drug in adult participants with Dermatomyositis (DM) from a qualifying
study.
expand
The purpose of this research study is to evaluate the long-term safety, and tolerability of PF-06823859 study drug in adult participants with Dermatomyositis (DM) from a qualifying study. Type: Interventional Start Date: Dec 2021 |
Study of Efficacy and Safety of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis
United Therapeutics
Idiopathic Pulmonary Fibrosis
Interstitial Lung Disease
Study RIN-PF-301 is designed to evaluate the safety and efficacy of inhaled treprostinil in
subjects with idiopathic pulmonary fibrosis (IPF) over a 52-week period.
expand
Study RIN-PF-301 is designed to evaluate the safety and efficacy of inhaled treprostinil in subjects with idiopathic pulmonary fibrosis (IPF) over a 52-week period. Type: Interventional Start Date: Jun 2021 |
Tenecteplase in Stroke Patients Between 4.5 and 24 Hours
Genentech, Inc.
THROMBOLYSIS
This study will evaluate the efficacy and safety of tenecteplase compared with placebo in
participants with acute ischemic stroke (AIS).
All participants will receive standard-of-care therapy according to AmericanHeart
Association/American Stroke Association clinical guidelines... expand
This study will evaluate the efficacy and safety of tenecteplase compared with placebo in participants with acute ischemic stroke (AIS). All participants will receive standard-of-care therapy according to AmericanHeart Association/American Stroke Association clinical guidelines (2018). To determine eligibility for randomization, all participants will undergo multimodal CT or MRI at baseline. Only participants with a vessel occlusion (ICA or MCA M1/M2) and penumbral tissue will be randomized. The primary analysis is to compare the efficacy of tenecteplase versus placebo in all participants at Day 90. Type: Interventional Start Date: Mar 2019 |
Evaluation of the Efficacy and Mechanisms of a Novel Intervention for Chronic Pain Tailored to People...
University of Pittsburgh
Chronic Pain
Due to its prevalence and impact on quality of life and overall health, the National Academy
of Medicine has called chronic pain a "public health crisis." Therefore, this proposal is
relevant to public health because it seeks to improve chronic pain treatment in accordance... expand
Due to its prevalence and impact on quality of life and overall health, the National Academy of Medicine has called chronic pain a "public health crisis." Therefore, this proposal is relevant to public health because it seeks to improve chronic pain treatment in accordance with the approach recommended by the Department of Health and Human Services National Pain Strategy: to develop and test Pain Self-Management interventions tailored to the needs of vulnerable populations, particularly people living with HIV (PLWH). Chronic pain is an important and understudied comorbidity among PLWH; therefore, this proposal is responsive to the NIH's HIV Research Priorities, which identify comorbidities as a high priority research topic. Type: Interventional Start Date: Aug 2019 |
Efficacy and Safety of KD025 in Subjects With cGVHD After At Least 2 Prior Lines of Systemic Therapy
Kadmon, a Sanofi Company
Chronic Graft-versus-host-disease
This is a Phase 2, randomized, multicenter study to evaluate the efficacy and safety of KD025
in subjects with Chronic Graft Versus Host Disease (cGVHD) after at least 2 prior lines of
systemic therapy
expand
This is a Phase 2, randomized, multicenter study to evaluate the efficacy and safety of KD025 in subjects with Chronic Graft Versus Host Disease (cGVHD) after at least 2 prior lines of systemic therapy Type: Interventional Start Date: Oct 2018 |
Study of STRO-001, an Anti-CD74 Antibody Drug Conjugate, in Patients With Advanced B-Cell Malignancies
Sutro Biopharma, Inc.
B-cell Lymphoma
Non Hodgkin Lymphoma
Multiple Myeloma
Follicular Lymphoma
Mantle Cell Lymphoma
First-in-human Phase 1 trial to study the safety, pharmacokinetics and preliminary efficacy
of STRO-001 given intravenously every 3 weeks.
expand
First-in-human Phase 1 trial to study the safety, pharmacokinetics and preliminary efficacy of STRO-001 given intravenously every 3 weeks. Type: Interventional Start Date: Feb 2018 |
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)
Center for International Blood and Marrow Transplant Research
Hematologic Malignancies
Inherited Disorders of Metabolism
Inherited Abnormalities of Platelets
Histiocytic Disorders
Acute Myelogenous Leukemia (AML or ANLL)
This study is an access and distribution protocol for unlicensed cryopreserved cord blood
units (CBUs) in pediatric and adult patients with hematologic malignancies and other
indications.
expand
This study is an access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) in pediatric and adult patients with hematologic malignancies and other indications. Type: Observational Start Date: Oct 2011 |
Scotoma Perimetry Oculomotor Training
University of Alabama at Birmingham
Macular Degeneration
Central Visual Impairment
The proposed research is relevant to public health because a greater understanding of
plasticity after central vision loss can inform new therapies for treating low vision and has
potential to benefit millions of individuals suffering from low vision. The treatment of low... expand
The proposed research is relevant to public health because a greater understanding of plasticity after central vision loss can inform new therapies for treating low vision and has potential to benefit millions of individuals suffering from low vision. The treatment of low vision is particularly relevant to the mission of the NEI to support research on visual disorders, mechanisms of visual function and preservation of sight. Declines in vision are particularly common in older adults and thus increasing our understanding of how to cre- ate effective means of improving vision is also highly relevant to the mission of the NIA to support research on aging and the health and well-being of older people. Type: Interventional Start Date: Sep 2022 |
A Phase 1/2/3 Study to Evaluate the Safety, Tolerability, and Immunogenicity of an RNA Vaccine Candidate...
BioNTech SE
SARS-CoV-2 Infection, COVID-19
This is a Phase 1/2/3 study in healthy children and young adults.
Dependent upon safety and/or immunogenicity data generated during the course of this study,
and the resulting assessment of benefit-risk, the safety, tolerability, and immunogenicity of
BNT162b2 in participants... expand
This is a Phase 1/2/3 study in healthy children and young adults. Dependent upon safety and/or immunogenicity data generated during the course of this study, and the resulting assessment of benefit-risk, the safety, tolerability, and immunogenicity of BNT162b2 in participants <6 months of age may subsequently be evaluated. Type: Interventional Start Date: Mar 2021 |
Combination Study With Eftilagimod Alpha (a Soluble LAG-3 Fusion Protein) and Pembrolizumab in Patients...
Immutep S.A.S.
HNSCC
Evaluate the safety and efficacy of eftilagimod alpha in combination with pembrolizumab
against pembrolizumab alone in 1st line metastatic or recurrent HNSCC with PD-L1 positive
(CPS ≥1) tumors, and determine the efficacy and safety of efti plus pembrolizumab in patients
with... expand
Evaluate the safety and efficacy of eftilagimod alpha in combination with pembrolizumab against pembrolizumab alone in 1st line metastatic or recurrent HNSCC with PD-L1 positive (CPS ≥1) tumors, and determine the efficacy and safety of efti plus pembrolizumab in patients with PD-L1 negative tumors. Type: Interventional Start Date: Aug 2021 |
Ultrasound-facilitated, Catheter-directed, Thrombolysis in Intermediate-high Risk Pulmonary Embolism
Boston Scientific Corporation
Pulmonary Embolism
There are many available treatments for pulmonary embolism (PE), but the best treatment for
this condition is not known. The HI-PEITHO study will compare two treatment options that are
both available on the market for the treatment of PE.
Patients will be randomized 1:1... expand
There are many available treatments for pulmonary embolism (PE), but the best treatment for this condition is not known. The HI-PEITHO study will compare two treatment options that are both available on the market for the treatment of PE. Patients will be randomized 1:1 to receive either blood thinners (anticoagulation) or blood thinners (anticoagulation) in combination with a device called the EkoSonicTM Endovascular device to dissolve blood clots. Patients will be followed for 12 months after randomization and have assessments while in the hospital as well as at 7 days, 30 days, 6 months and 12 months after randomization. The study will try to find out if one of these treatments is better than the other at reducing the risk of death and other serious problems. Type: Interventional Start Date: Aug 2021 |
LUX-Dx TRENDS Evaluates Diagnostics Sensors in Heart Failure Patients Receiving Boston Scientific's Investigational...
Boston Scientific Corporation
Heart Failure
The primary objective of this study is to collect sensor data from insertable cardiac monitor
systems.
expand
The primary objective of this study is to collect sensor data from insertable cardiac monitor systems. Type: Interventional Start Date: Mar 2021 |
A Placebo-controlled Study of Volixibat in Subjects With Elevated Serum Bile Acids Associated With Intrahepatic...
Mirum Pharmaceuticals, Inc.
Intrahepatic Cholestasis of Pregnancy
The purpose of this clinical research study is to evaluate the efficacy, safety and
tolerability of the study medicine, volixibat, in patients with Intrahepatic cholestasis of
pregnancy (ICP) and elevated serum bile acid concentrations.
expand
The purpose of this clinical research study is to evaluate the efficacy, safety and tolerability of the study medicine, volixibat, in patients with Intrahepatic cholestasis of pregnancy (ICP) and elevated serum bile acid concentrations. Type: Interventional Start Date: Jan 2021 |