Search Clinical Trials
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Dose-Escalation Study of Cevostamab in Participants With Relapsed or Refractory Multiple Myeloma (R/R...
Genentech, Inc.
Multiple Myeloma
This is a phase I, multicenter, open-label, dose-escalation study of cevostamab
administered as a single agent by IV infusion to participants with relapsed or refractory
multiple myeloma (R/R MM). expand
This is a phase I, multicenter, open-label, dose-escalation study of cevostamab administered as a single agent by IV infusion to participants with relapsed or refractory multiple myeloma (R/R MM). Type: Interventional Start Date: Sep 2017 |
Blue Light Cystoscopy With Cysview® Registry
Photocure
Bladder Cancer
Registry study to gather more information on the current use of Blue Light Cystoscopy
with Cysview (BLCC) in urologists' practices. expand
Registry study to gather more information on the current use of Blue Light Cystoscopy with Cysview (BLCC) in urologists' practices. Type: Observational [Patient Registry] Start Date: Apr 2014 |
Advancing Transplantation Outcomes in Children
National Institute of Allergy and Infectious Diseases (NIAID)
Kidney Transplant
This is a pediatric kidney transplant study comparing the safety and efficacy of an
immunosuppressive regimen of belatacept and sirolimus to tacrolimus and Mycophenolate
Mofetil (MMF). Two hundred participants will be randomized (1:1) to one of two groups
within 24 hours following the transplant procedure.... expand
This is a pediatric kidney transplant study comparing the safety and efficacy of an immunosuppressive regimen of belatacept and sirolimus to tacrolimus and Mycophenolate Mofetil (MMF). Two hundred participants will be randomized (1:1) to one of two groups within 24 hours following the transplant procedure. The duration of the study from time of transplant to the primary endpoint is 12-24 months. Type: Interventional Start Date: May 2024 |
Developing an Opioid Taper Intervention Before Total Joint Arthroplasty
University of Alabama at Birmingham
Arthritis Knee
Arthritis Hip
Chronic Pain
The goal of this clinical trial is to develop an pharmacist-led preoperative opioid taper
intervention for patients undergoing total knee or hip replacement who are on chronic
opioids before their surgery. The main questions it aims to answer are:
- Is the intervention feasible and acceptable... expand
The goal of this clinical trial is to develop an pharmacist-led preoperative opioid taper intervention for patients undergoing total knee or hip replacement who are on chronic opioids before their surgery. The main questions it aims to answer are: - Is the intervention feasible and acceptable to patients? - Does the intervention result in a decrease in opioid dose during the preoperative period? Participants will meet with a clinical pharmacist, who will provide some basic education on pain and opioids, and will propose an opioid taper schedule. The pharmacist will then follow-up with the participant by phone each week until surgery to assess progress and adjust the taper as necessary. Type: Interventional Start Date: Jan 2024 |
A Pivotal Study to Evaluate the Efficacy of Lorundrostat in Subjects With Uncontrolled Hypertension on...
Mineralys Therapeutics Inc.
Hypertension
a Phase 2 trial to evaluate the blood pressure-lowering effect of lorundrostat (an
aldosterone synthase inhibitor), administered on a background of a standardized
anti-hypertensive (AHT) medication regimen, in subjects with uncontrolled and/or
treatment-resistant hypertension. expand
a Phase 2 trial to evaluate the blood pressure-lowering effect of lorundrostat (an aldosterone synthase inhibitor), administered on a background of a standardized anti-hypertensive (AHT) medication regimen, in subjects with uncontrolled and/or treatment-resistant hypertension. Type: Interventional Start Date: Mar 2023 |
Platelet Rich Plasma as an Adjunct Therapy at the Time of Transvaginal Native Tissue Prolapse Surgery
University of Alabama at Birmingham
Pelvic Organ Prolapse
The purpose of the study is to evaluate the surgical outcomes of injecting platelet-rich
plasma (PRP) into the vaginal tissue as an adjunct therapy at the time of prolapse
surgery expand
The purpose of the study is to evaluate the surgical outcomes of injecting platelet-rich plasma (PRP) into the vaginal tissue as an adjunct therapy at the time of prolapse surgery Type: Interventional Start Date: Jul 2023 |
A Phase 1b / 2 Drug Resistant Immunotherapy With Activated, Gene Modified Allogeneic or Autologous γδ...
In8bio Inc.
Glioblastoma
This multicenter, Phase 1b/2 study is being conducted to determine if the experimental
cell therapy is safe, tolerable and can delay the return of cancer in patients with a
newly diagnosed or recurrent glioblastoma multiforme (GBM) in combination with standard
chemotherapy treatment temozolomide (TMZ).... expand
This multicenter, Phase 1b/2 study is being conducted to determine if the experimental cell therapy is safe, tolerable and can delay the return of cancer in patients with a newly diagnosed or recurrent glioblastoma multiforme (GBM) in combination with standard chemotherapy treatment temozolomide (TMZ). If there is a 25% or greater improvement in survival in this study then the therapy should be studied further. Type: Interventional Start Date: Sep 2023 |
The Patient and Family Centered I-PASS LISTEN Study: Language, Inclusion, Safety, and Teamwork for Equity...
Boston Children's Hospital
Communication
In 2014, a team of parents, nurses, and physicians created Patient and Family Centered
I-PASS (PFC I-PASS), a bundle of communication interventions to improve the quality of
information exchange between physicians, nurses, and families, and to better integrate
families into all aspects of daily decision... expand
In 2014, a team of parents, nurses, and physicians created Patient and Family Centered I-PASS (PFC I-PASS), a bundle of communication interventions to improve the quality of information exchange between physicians, nurses, and families, and to better integrate families into all aspects of daily decision making in hospitals. PFC I-PASS changed how doctors and nurses talk to patients and families on rounds when they're admitted to the hospital. (Rounds are when a team of doctors visit patients every morning to do a checkup and make a plan for the day.) Rounds used to happen in a way that left out patients and families. Doctors talked at, not with patients, used big words and medical talk, and left nurses out. PFC I-PASS changed rounds by including families and nurses, using simple non-medical words, and talking in an organized way so nothing is left out. When PFC I-PASS was put in place in 7 hospitals, patients had fewer adverse events and better hospital experience. But it didn't focus on how to talk with patients with language barriers. This project builds upon upon PFC I-PASS to make it better and focus on the special needs of patients who speak languages other than English. This new intervention is known as PFC I-PASS+. PFC I-PASS+ includes all parts of PFC I-PASS plus having interpreters on and after rounds and training doctors about communication and cultural humility. The study team will now conduct a stepped-wedge cluster randomized trial to compare the effectiveness of PFC I-PASS+ and PFC I-PASS to usual care at 8 hospitals. Type: Interventional Start Date: Mar 2024 |
Therapeutic Mechanisms of Epidural Spinal Cord Stimulation
University of Alabama at Birmingham
Blood Pressure
Low Back Pain
Hypertension
The purpose of this study in patients undergoing routine care epidural spinal cord
stimulation (SCS) is to determine 1) whether SCS reduces arterial blood pressure (BP) in
patients which chronic low back pain and hypertension, 2) whether higher baseline BP
(i.e., hypertension) predicts reductions... expand
The purpose of this study in patients undergoing routine care epidural spinal cord stimulation (SCS) is to determine 1) whether SCS reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension, 2) whether higher baseline BP (i.e., hypertension) predicts reductions in pain following SCS, and finally 3) whether different SCS waveforms elicits stimulus-evoked compound action potentials (ECAPs) in spinal cord and at the cortex (electroencephalography, and magnetoenchphalography). Type: Interventional Start Date: Aug 2022 |
Multi-Center Molecular Diagnosis and Host Response of Respiratory Viral Infections in Pediatric Transplant...
St. Jude Children's Research Hospital
Hematopoietic Cell Transplant
Solid Organ Transplant
Respiratory Viral Infection
The participants are being asked to take part in this clinical trial, a type of research
study, because the participants are scheduled to receive or have recently received a
hematopoietic cell transplant (HCT) or a solid organ transplant (SOT).
Primary Objective
To determine if pre-transplant... expand
The participants are being asked to take part in this clinical trial, a type of research study, because the participants are scheduled to receive or have recently received a hematopoietic cell transplant (HCT) or a solid organ transplant (SOT). Primary Objective To determine if pre-transplant screening for respiratory viral load predicts RVI within 1- year post-transplant among survivors. Secondary Objectives: - To develop and validate a classifier based on pre-transplant immunological profile predictive of developing an acute respiratory viral infection (aRVI), with RSV/PIV3/HMPV/SARS-CoV-2 through one-year post-transplant among survivors. - To develop and validate a classifier based on Day +100 post-transplant immunological profiles predictive of developing an acute respiratory viral infection (aRVI),with RSV/PIV3/HMPV/SARS-CoV-2 through one-year post-transplant among survivors . Type: Observational Start Date: Dec 2022 |
Reduced-dose Botox for Urgency Incontinence Among Elder Females
Dartmouth-Hitchcock Medical Center
Overactive Bladder
Urinary Incontinence in Old Age
Urgency Urinary Incontinence
The purpose of this study is to study the treatment of urgency urinary incontinence
(UUI), specifically among women 70 years and older, by comparing reduced versus standard
dose of onabotulinumtoxinA (BTX; trade name BOTOX(c)) injection in the bladder. expand
The purpose of this study is to study the treatment of urgency urinary incontinence (UUI), specifically among women 70 years and older, by comparing reduced versus standard dose of onabotulinumtoxinA (BTX; trade name BOTOX(c)) injection in the bladder. Type: Interventional Start Date: May 2023 |
Regorafenib and Durvalumab for the Treatment of High-Risk Liver Cancer
Academic and Community Cancer Research United
Stage IB Hepatocellular Carcinoma AJCC v8
Stage II Hepatocellular Carcinoma AJCC v8
Stage III Hepatocellular Carcinoma AJCC v8
Stage IIIA Hepatocellular Carcinoma AJCC v8
This phase II trial tests whether regorafenib and durvalumab work to shrink tumors in
patients with high-risk liver cancer. Regorafenib may stop the growth of tumor cells by
blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal
antibodies, such as durvalumab, may help... expand
This phase II trial tests whether regorafenib and durvalumab work to shrink tumors in patients with high-risk liver cancer. Regorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer and may interfere with the ability of tumor cells to grow and spread. Giving regorafenib and durvalumab may work better in treating patients with high-risk liver cancer. Type: Interventional Start Date: Jul 2023 |
Study of Tirabrutinib (ONO-4059) in Patients With Primary Central Nervous System Lymphoma (PROSPECT Study)
Ono Pharmaceutical Co. Ltd
Refractory Primary Central Nervous System Lymphoma
Primary CNS Lymphoma
This study will evaluate the efficacy, safety, and pharmacokinetics of tirabrutinib
monotherapy in patients with relapsed or refractory PCNSL (Part A), and tirabrutinib in
combination with one of two different high dose methotrexate based regimens
(methotrexate/ temozolomide/rituximab or rituximab/methotrexate/procarbazine/
vincristine)... expand
This study will evaluate the efficacy, safety, and pharmacokinetics of tirabrutinib monotherapy in patients with relapsed or refractory PCNSL (Part A), and tirabrutinib in combination with one of two different high dose methotrexate based regimens (methotrexate/ temozolomide/rituximab or rituximab/methotrexate/procarbazine/ vincristine) as first line therapy in patients with newly diagnosed, treatment naïve PCNSL (Part B) Type: Interventional Start Date: Dec 2021 |
Non-Invasive Monitoring of Traumatic Brain Injury Progression Using the Infrascanner (MOBI-1)
University of Alabama at Birmingham
Brain Injuries, Traumatic
MOBI-1 is a multicenter clinical trial that will evaluate the use of the Infrascanner for
the monitoring of traumatic intracranial hematomas. expand
MOBI-1 is a multicenter clinical trial that will evaluate the use of the Infrascanner for the monitoring of traumatic intracranial hematomas. Type: Observational Start Date: Apr 2022 |
A Study of Etavopivat in Adults and Adolescents With Sickle Cell Disease (HIBISCUS)
Forma Therapeutics, Inc.
Sickle Cell Disease
This clinical trial is a Phase 2/3 study that will evaluate the efficacy and safety of
etavopivat and test how well etavopivat works compared to placebo to improve the amount
of hemoglobin in the blood and to reduce the number of vaso-occlusive crises (times when
the blood vessels become blocked and... expand
This clinical trial is a Phase 2/3 study that will evaluate the efficacy and safety of etavopivat and test how well etavopivat works compared to placebo to improve the amount of hemoglobin in the blood and to reduce the number of vaso-occlusive crises (times when the blood vessels become blocked and cause pain). Type: Interventional Start Date: Mar 2021 |
Evolutionary Therapy for Rhabdomyosarcoma
H. Lee Moffitt Cancer Center and Research Institute
Rhabdomyosarcoma
This clinical trial will evaluate 4 different strategies of chemotherapy schedules in
newly diagnosed participants with metastatic Fusion Positive (alveolar) Rhabdomyosarcoma.
The participant and their physician will choose from: Arm A) a first strike therapy, Arm
B) a first strike-second strike (maintenance)... expand
This clinical trial will evaluate 4 different strategies of chemotherapy schedules in newly diagnosed participants with metastatic Fusion Positive (alveolar) Rhabdomyosarcoma. The participant and their physician will choose from: Arm A) a first strike therapy, Arm B) a first strike-second strike (maintenance) therapy, Arm C) an adaptively timed therapy, and Arm D) conventional chemotherapy. Type: Interventional Start Date: Sep 2020 |
A Safety Study of SEA-CD70 in Patients With Myeloid Malignancies
Seagen Inc.
Myelodysplastic Syndrome
Acute Myeloid Leukemia
This trial will look at a drug called SEA-CD70 with and without azacitidine, to find out
if it is safe for patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia
(AML). It will study SEA-CD70 to find out what its side effects are and if it works for
AML and MDS. A side effect is anything... expand
This trial will look at a drug called SEA-CD70 with and without azacitidine, to find out if it is safe for patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). It will study SEA-CD70 to find out what its side effects are and if it works for AML and MDS. A side effect is anything the drug does besides treating cancer. This study will have six groups or "parts." - Part A will find out how much SEA-CD70 should be given to patients. - Part B will use the dose found in Part A to find out how safe SEA-CD70 is and if it works to treat patients with MDS. - Part C will use the dose found in Part A to find out how safe SEA-CD70 is and if it works to treat patients with AML. - Part D will find out how much SEA-CD70 with azacitidine should be given to patients. - Part E will use the dose found in Part D to find out how safe SEA-CD70 with azacitidine is and if it works to treat patients with MDS or MDS/AML that has not been treated. - Part F will use the dose found in Part D to find out how safe SEA-CD70 with azacitidine is and if it works to treat patients with MDS or MDS/AML. Type: Interventional Start Date: Aug 2020 |
A Peer-Led Intervention to Improve Postpartum Retention in HIV Care
University of Pennsylvania
HIV/AIDS
The purpose of this study is to test the efficacy of a theory-driven peer intervention
for pregnant and postpartum women living HIV. The peer intervention is designed to
increase self-efficacy, social support, self-regulatory behaviors, and outcome expectancy
in order to improve retention in care... expand
The purpose of this study is to test the efficacy of a theory-driven peer intervention for pregnant and postpartum women living HIV. The peer intervention is designed to increase self-efficacy, social support, self-regulatory behaviors, and outcome expectancy in order to improve retention in care and viral suppression postpartum. The intervention will consist of face-to-face prenatal educational sessions, starting in early third trimester, and postpartum sessions scheduled up to three months postpartum. Type: Interventional Start Date: Mar 2020 |
An Exercise Intervention to Improve Overall Brain Health
University of Alabama at Birmingham
Brain Care Score
Exercise
Hypertension
BMI
The goal of this clinical trial is to test the effects of 10 weeks of exercise on overall
brain health, reduction in blood pressure, and the number of blood vessels in the back of
the eyes in patients with hypertension and have a body mass index ≥ 25 kg/m2. The main
question[s] it aims to answer are:... expand
The goal of this clinical trial is to test the effects of 10 weeks of exercise on overall brain health, reduction in blood pressure, and the number of blood vessels in the back of the eyes in patients with hypertension and have a body mass index ≥ 25 kg/m2. The main question[s] it aims to answer are: - To test the effect of moderate vs intensive exercise on Brain Care Score outcomes. - To ascertain the differential impact of moderate vs high intensity exercise in reducing hypertension and its downstream effects. Type: Interventional Start Date: Jan 2024 |
Study on Use of Omega-3 Fatty Acids to Improve Outcomes in Individuals With Sickle Cell Disease
University of Alabama at Birmingham
Sickle Cell Disease
Sickle cell disease (SCD) is associated with significant morbidity and mortality. Pain
and many adverse outcomes occurring in sickle cell disease are inflammatory driven.
Recent data has shown that gut dysbiosis is present in individuals with sickle cell
disease. Gut dysbiosis has been linked to inflammation... expand
Sickle cell disease (SCD) is associated with significant morbidity and mortality. Pain and many adverse outcomes occurring in sickle cell disease are inflammatory driven. Recent data has shown that gut dysbiosis is present in individuals with sickle cell disease. Gut dysbiosis has been linked to inflammation in certain diseases. Omega -3-fatty acids (fish oil) has been shown to improve pain outcomes in individuals with sickle cell disease, but its acceptance is variable. The aim of this study is to determine if a plant-based omega-3-fatty acids will be more acceptable and also improve outcomes in individuals with sickle cell disease Type: Interventional Start Date: Aug 2023 |
Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT
University of Alabama at Birmingham
Orthopedic Disorder
Anterior Cruciate Ligament Injuries
The choice of autograft for ACL reconstruction continues to be debated. To date, there
has only be one completed randomized controlled trial with quad tendon to BTB and the
tendon included a bone plug. There has been no study to date comparing an all soft tissue
quad tendon to patellar tendon in a... expand
The choice of autograft for ACL reconstruction continues to be debated. To date, there has only be one completed randomized controlled trial with quad tendon to BTB and the tendon included a bone plug. There has been no study to date comparing an all soft tissue quad tendon to patellar tendon in a randomized controlled trial for ACL reconstruction. Type: Interventional Start Date: Sep 2023 |
Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer...
National Cancer Institute (NCI)
Bladder Adenocarcinoma
Bladder Clear Cell Adenocarcinoma
Bladder Mixed Adenocarcinoma
Bladder Neuroendocrine Carcinoma
Bladder Small Cell Neuroendocrine Carcinoma
This phase II trial studies how well cabozantinib works in combination with nivolumab and
ipilimumab in treating patients with rare genitourinary (GU) tumors that has spread from
where it first started (primary site) to other places in the body. Cabozantinib may stop
the growth of tumor cells by blocking... expand
This phase II trial studies how well cabozantinib works in combination with nivolumab and ipilimumab in treating patients with rare genitourinary (GU) tumors that has spread from where it first started (primary site) to other places in the body. Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving cabozantinib, nivolumab, and ipilimumab may work better in treating patients with genitourinary tumors that have no treatment options compared to giving cabozantinib, nivolumab, or ipilimumab alone. Type: Interventional Start Date: May 2019 |
UAB Alzheimer's Disease Center Core Cohort - Imaging Substudy
University of Alabama at Birmingham
Alzheimer Disease
The primary objective of this study is to measure the concentration and the regional
brain distribution of pathologic amyloid deposition using the PET tracer [C-11]PiB in
participants in the UAB Alzheimer's Disease Center cohort. Assessment of interactions
between race and vascular risk factors, brain... expand
The primary objective of this study is to measure the concentration and the regional brain distribution of pathologic amyloid deposition using the PET tracer [C-11]PiB in participants in the UAB Alzheimer's Disease Center cohort. Assessment of interactions between race and vascular risk factors, brain amyloid levels measured with [C-11]PiB-PET, and cognitive status will be the primary outcome of this imaging study. Type: Interventional Start Date: Apr 2018 |
Rituximab With or Without Stem Cell Transplant in Treating Patients With Minimal Residual Disease-Negative...
ECOG-ACRIN Cancer Research Group
CD20 Positive
Mantle Cell Lymphoma
This randomized phase III trial studies rituximab after stem cell transplant and to see
how well it works compared with rituximab alone in treating patients with in minimal
residual disease-negative mantle cell lymphoma in first complete remission. Monoclonal
antibodies, such as rituximab, may interfere... expand
This randomized phase III trial studies rituximab after stem cell transplant and to see how well it works compared with rituximab alone in treating patients with in minimal residual disease-negative mantle cell lymphoma in first complete remission. Monoclonal antibodies, such as rituximab, may interfere with the ability of cancer cells to grow and spread. Giving chemotherapy before a stem cell transplant helps kill any cancer cells that are in the body and helps make room in the patient's bone marrow for new blood-forming cells (stem cells) to grow. After treatment, stem cells are collected from the patient's blood and stored. More chemotherapy is then given to prepare the bone marrow for the stem cell transplant. The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy. Giving rituximab with or without stem cell transplant may work better in treating patients with mantle cell lymphoma. Type: Interventional Start Date: Mar 2018 |
Refining the Role of Mid-induction Bone Marrow Biopsy in Acute Myeloid Leukemia: A Pilot Study
University of Alabama at Birmingham
Acute Myeloid Leukemia
The purpose of the study is to observe the outcomes of patients with acute myeloid
leukemia who do not receive an immediate second round of chemotherapy after undergoing a
standard mid-induction bone marrow biopsy. expand
The purpose of the study is to observe the outcomes of patients with acute myeloid leukemia who do not receive an immediate second round of chemotherapy after undergoing a standard mid-induction bone marrow biopsy. Type: Observational Start Date: May 2024 |
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