Search Clinical Trials
Sponsor Condition of Interest |
---|
Cord Clamping Among Neonates With Congenital Heart Disease
Carl Backes, MD
Congenital Heart Disease (CHD)
The goal of this clinical trial is to compare 2 different timepoints for clamping the
umbilical cord at birth for term-born infants with a prenatal diagnosis of congenital
heart disease (CHD). The main questions it aims to answer are:
- Does Delayed Cord Clamping at 120 seconds (DCC-120) or Delayed... expand
The goal of this clinical trial is to compare 2 different timepoints for clamping the umbilical cord at birth for term-born infants with a prenatal diagnosis of congenital heart disease (CHD). The main questions it aims to answer are: - Does Delayed Cord Clamping at 120 seconds (DCC-120) or Delayed Cord Clamping at 30 seconds (DCC-30) after birth lead to better health outcomes? - Does DCC-120 seconds or DCC-30 seconds after birth lead to better neuromotor outcomes at 22-26 months of infant age (postnatal)? Participants will be asked to do the following: - Participate in either DCC-120 or DCC-30 at birth (randomized assignment). - Complete General Movements Assessment (GMA) at 3-4 months of infant age (postnatal), complete questionnaires / surveys at this time. - Complete questionnaires / surveys at 9-12 months of infant age (postnatal). - Complete Hammersmith Infant Neurological Examination (HINE), Developmental Assessment of Young Children 2 Edition (DAYC-2), and questionnaires / surveys at 22-26 months of infant age (postnatal). - Permit data collection from electronic medical records for both the mother and infant study participants. Investigators will compare DCC-120 vs. DCC-30 to see which approach is more beneficial to both the mother and baby with CHD. Type: Interventional Start Date: Dec 2023 |
Testing the Role of FDG-PET/CT to Predict Response to Therapy Prior to Surgery for HER2-positive Breast...
ECOG-ACRIN Cancer Research Group
Anatomic Stage II Breast Cancer AJCC v8
Anatomic Stage III Breast Cancer AJCC v8
HER2-Positive Breast Carcinoma
Invasive Breast Carcinoma
This phase II trial tests how well an imaging procedure called fludeoxyglucose F-18 (FDG)
positron emission tomography/computed tomography (PET/CT) works in predicting response to
standard of care chemotherapy prior to surgery in patients with HER2-positive stage
IIa-IIIc breast cancer. FDG is a radioactive... expand
This phase II trial tests how well an imaging procedure called fludeoxyglucose F-18 (FDG) positron emission tomography/computed tomography (PET/CT) works in predicting response to standard of care chemotherapy prior to surgery in patients with HER2-positive stage IIa-IIIc breast cancer. FDG is a radioactive tracer that is given in a vein before PET/CT imaging and helps to identify areas of active cancer. PET and CT are imaging techniques that make detailed, computerized pictures of areas inside the body. The use of FDG-PET/CT may help doctors better decide if a patient needs more or less treatment before surgery in order to get the best response. This study evaluates whether FDG-PET/CT is useful in predicting a patient's response to standard of care chemotherapy. Type: Interventional Start Date: May 2023 |
Integrated Care and Treatment for Severe Infectious Diseases and Substance Use Disorders Among Hospitalized...
Columbia University
Injection Site Infection
Substance Use Disorders
The goal of this clinical trial is to test the effectiveness of an integrated infectious
disease/substance use disorder (SUD) clinical team intervention approach in patients
hospitalized with severe injection-related infections (SIRI) who use drugs. The main
question this study aims to answer is whether... expand
The goal of this clinical trial is to test the effectiveness of an integrated infectious disease/substance use disorder (SUD) clinical team intervention approach in patients hospitalized with severe injection-related infections (SIRI) who use drugs. The main question this study aims to answer is whether this intervention approach will be associated with lower mortality and fewer hospital readmissions. Participants will participate in the integrated SUD/ID care team intervention (SIRI Team). Researchers will compare this intervention to treatment as usual (TUA) to see if there are any differences in health outcomes. Type: Interventional Start Date: Jan 2024 |
Cardiometabolic Health Intervention Using Movement-to-Music Exercise
University of Alabama at Birmingham
Cardiometabolic Risk Factors in Adult Wheelchair Users
The study aims to test the benefits of a 24-week, cardio-emphasized Movement-to-Music
exercise program for reversing cardiometabolic health risk factors compared to
asynchronous, standard exercise programs among 132 adult wheelchair users. The targeted
cardiometabolic health factors are waist circumference,... expand
The study aims to test the benefits of a 24-week, cardio-emphasized Movement-to-Music exercise program for reversing cardiometabolic health risk factors compared to asynchronous, standard exercise programs among 132 adult wheelchair users. The targeted cardiometabolic health factors are waist circumference, triglycerides, "good" cholesterol, glucose, and blood pressure. Additionally, a 12-week follow-up phase (weeks 25-36) is included to see whether the gains are maintained. Type: Interventional Start Date: Sep 2023 |
Study of CC-96191 in Participants With Relapsed or Refractory Acute Myeloid Leukemia
Celgene
Leukemia, Myeloid
This Phase 1, clinical study of CC-96191 will explore the safety, tolerability and
preliminary biological and clinical activity of CC-96191 as a single-agent in the setting
of Relapsed or refractory acute myeloid leukemia (R/R AML).
The dose escalation (Part A) of the study will explore escalating... expand
This Phase 1, clinical study of CC-96191 will explore the safety, tolerability and preliminary biological and clinical activity of CC-96191 as a single-agent in the setting of Relapsed or refractory acute myeloid leukemia (R/R AML). The dose escalation (Part A) of the study will explore escalating intravenous doses of CC-96191 to estimate the MTD and/or RP2D of CC-96191 as monotherapy. The expansion (Part B), will further evaluate the safety and efficacy of CC-96191 administered at or below the MTD in one or more expansion cohorts in order to determine the RP2D. Type: Interventional Start Date: Jun 2021 |
CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy for Relapsed/Refractory B Cell Non-Hodgkin Lymphoma...
Caribou Biosciences, Inc.
Lymphoma, Non-Hodgkin
Relapsed Non Hodgkin Lymphoma
Refractory B-Cell Non-Hodgkin Lymphoma
Non Hodgkin Lymphoma
Lymphoma
CB010A is a study evaluating safety, emerging efficacy, pharmacokinetics and
immunogenicity of CB-010 in adults with relapsed/refractory B cell non-Hodgkin lymphoma
after lymphodepletion consisting of cyclophosphamide and fludarabine. expand
CB010A is a study evaluating safety, emerging efficacy, pharmacokinetics and immunogenicity of CB-010 in adults with relapsed/refractory B cell non-Hodgkin lymphoma after lymphodepletion consisting of cyclophosphamide and fludarabine. Type: Interventional Start Date: May 2021 |
A Study of [225Ac]-FPI-2059 in Adult Participants With Solid Tumours
Fusion Pharmaceuticals Inc.
Pancreatic Ductal Adenocarcinoma (PDAC)
Squamous Cell Carcinoma of Head and Neck
Colorectal Cancer
Gastric Cancer
Ewing Sarcoma
This is a first-in-human Phase 1 clinical trial designed to investigate the safety,
tolerability, pharmacokinetics, and biodistribution of [225Ac]-FPI-2059 and
[111In]-FPI-2058 in participants with neurotensin receptor 1 (NTSR1)-expressing solid
tumours. expand
This is a first-in-human Phase 1 clinical trial designed to investigate the safety, tolerability, pharmacokinetics, and biodistribution of [225Ac]-FPI-2059 and [111In]-FPI-2058 in participants with neurotensin receptor 1 (NTSR1)-expressing solid tumours. Type: Interventional Start Date: Feb 2023 |
Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting...
National Cancer Institute (NCI)
Recurrent Biliary Tract Carcinoma
Recurrent Distal Cholangiocarcinoma
Recurrent Gallbladder Carcinoma
Recurrent Intrahepatic Cholangiocarcinoma
Stage III Distal Bile Duct Cancer AJCC v8
This phase II ComboMATCH treatment trial compares the usual treatment of modified
leucovorin, fluorouracil and oxaliplatin (mFOLFOX6) chemotherapy to using binimetinib
plus mFOLFOX6 chemotherapy to shrink tumors in patients with biliary tract cancers that
have spread to other places in the body (advanced)... expand
This phase II ComboMATCH treatment trial compares the usual treatment of modified leucovorin, fluorouracil and oxaliplatin (mFOLFOX6) chemotherapy to using binimetinib plus mFOLFOX6 chemotherapy to shrink tumors in patients with biliary tract cancers that have spread to other places in the body (advanced) and had progression of cancer after previous treatments (2nd line setting). Fluorouracil is in a class of medications called antimetabolites. It works by slowing or stopping the growth of cancer cells in the body. Oxaliplatin is in a class of medications called platinum-containing antineoplastic agents. It works by killing tumor cells. Leucovorin may help the other drugs in the mFOLFOX6 chemotherapy regimen work better by making tumor cells more sensitive to the drugs. Binimetinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals tumor cells to multiply. This helps to stop or slow the spread of tumor cells. Giving binimetinib in combination with mFOLFOX6 chemotherapy may be effective in shrinking or stabilizing advanced biliary tract cancers in the 2nd line setting. Type: Interventional Start Date: Feb 2024 |
Constraint-Induced Movement Therapy for Adults Post-Stroke With Mild Upper Extremity Impairment
University of Alabama at Birmingham
CVA (Cerebrovascular Accident)
Stroke
Upper Extremity Paresis
Constraint-Induced Therapy (CI Therapy) is a behavioral approach to neurorehabilitation
and consists of multi-components that have been applied in a systematic method to improve
the use of the limb or function addressed in the intensive treatment. CI Therapy for the
more-affected upper extremity (UE)... expand
Constraint-Induced Therapy (CI Therapy) is a behavioral approach to neurorehabilitation and consists of multi-components that have been applied in a systematic method to improve the use of the limb or function addressed in the intensive treatment. CI Therapy for the more-affected upper extremity (UE) post-stroke is administered in daily treatment sessions over consecutive weekdays. Sessions include motor training with repeated, timed trials using a technique called shaping, a set of behavioral strategies known as the Transfer Package (TP) to improve the use of the more-affected hand in the life situation, and strategies to remind participants to use the more-affected UE including restraint. Robust improvements in the amount and qualify of use have been realized with stroke participants from mild-to-severe UE impairment. Type: Interventional Start Date: Dec 2022 |
Comparing Game Facilitated Interactivity to Genetic Counseling for Prenatal Screening Education
Erin Rothwell
Genetic Counseling
Shared Decision Making
Pregnancy
Genetic Testing
Prenatal Disorder
Advancements in prenatal genetic screening have significantly improved the identification
of chromosomal abnormalities and heritable conditions during pregnancy, yet current
standards for patient education in this domain are largely ineffective. The most
effective approach to education about prenatal... expand
Advancements in prenatal genetic screening have significantly improved the identification of chromosomal abnormalities and heritable conditions during pregnancy, yet current standards for patient education in this domain are largely ineffective. The most effective approach to education about prenatal screening is one-on-one genetic counseling, but due to the limited number of counselors this is not feasible, especially in rural and frontier areas. The investigators will address this national problem using a novel education game that can more effectively address this gap in healthcare decision-making. Type: Interventional Start Date: Mar 2023 |
ViTAA Registry Pre- and Post-Operative Monitoring for Endovascular Aortic Aneurysm Repair and Serial...
ViTAA Medical Solutions
Abdominal Aortic Aneurysms
This is a Prospective Registry study to collect imaging and clinical data both on
patients with aortic aneurysm disease undergoing serial monitoring and on patients pre
and post-endovascular repair, using ViTAA (The Sponsor) aortic mapping technology. expand
This is a Prospective Registry study to collect imaging and clinical data both on patients with aortic aneurysm disease undergoing serial monitoring and on patients pre and post-endovascular repair, using ViTAA (The Sponsor) aortic mapping technology. Type: Observational [Patient Registry] Start Date: Dec 2021 |
MicroRNA Correlates of Childhood Maltreatment and Suicidality
University of Alabama at Birmingham
Major Depressive Disorder
Suicidal Ideation
This is a research study to find out if childhood trauma and stress are associated with
depression or suicidal risk. The study will assess the effects of both short-term and
long-term stress on biomarker (e.g. miRNA [MiRNA]) levels. miRNAs are a type of RNA
(genetic material that is translated into... expand
This is a research study to find out if childhood trauma and stress are associated with depression or suicidal risk. The study will assess the effects of both short-term and long-term stress on biomarker (e.g. miRNA [MiRNA]) levels. miRNAs are a type of RNA (genetic material that is translated into protein) that are found in throughout the body and blood. They are called microRNA because their size is much smaller than typical RNA molecules. miRNAs are highly responsive to environment. This responsiveness is reflected in their expression in individuals who are affected by environment such as stress. The investigators are gathering genetic material, including DNA and RNA, from each participant. The RNA will be taken from the small vesicles and cells in the participant's blood and analyzed. The vesicles are small objects that occur normally in the blood and that contain RNA. This information may help us to understand the cause of mental illness and to improve medical and psychiatric care in the future. There will be 450 participants enrolled in this study. Type: Observational Start Date: Feb 2021 |
Office-Based Superior Laryngeal Nerve Block for Treatment of Neurogenic Cough
University of Alabama at Birmingham
Cough
The purpose of this study is to evaluate if office-based injection of a local
anesthetic/steroid combination at the area of one superior laryngeal nerve can decrease
cough frequency and alleviate symptoms of chronic cough in patients with neurogenic
cough. expand
The purpose of this study is to evaluate if office-based injection of a local anesthetic/steroid combination at the area of one superior laryngeal nerve can decrease cough frequency and alleviate symptoms of chronic cough in patients with neurogenic cough. Type: Observational Start Date: Jan 2022 |
A Motion Exergaming Approach for Symptom Management: HNC
University of Alabama at Birmingham
Head and Neck Cancer
This overall objective of the RCT is to test an intervention to overcome the PA barriers
for head and neck cancer (HNC) patients during the first 6 months after their treatment.
PAfitME stands for a personalized Physical Activity intervention with fitness graded
Motion Exergames. PAfitME is delivered... expand
This overall objective of the RCT is to test an intervention to overcome the PA barriers for head and neck cancer (HNC) patients during the first 6 months after their treatment. PAfitME stands for a personalized Physical Activity intervention with fitness graded Motion Exergames. PAfitME is delivered via a tested mix of FaceTime calls and home visits, uses commercially available exergaming platforms (Nintendo Switch). We propose the following specific aims: (1) When compared to an attention control group, determine the effect of PAfitME on fatigue and musculoskeletal pain at week 6, when controlling for age and sex; (2) when compared to an attention control group, determine the effect of PAfitME on functional status and QOL at week 6, when controlling for age and sex; and (3) explore if PA self-efficacy, PA enjoyment, and exergame minutes mediate the effect of PAfitME on fatigue and musculoskeletal pain. This study will evaluate 150 post-treatment (radiation, chemotherapy, or chemoradiation) HNC patients in an RCT with an attention control. For 6 weeks, the experimental (PAfitME) group will receive the PAfitME intervention, and the attention control group will receive NCI-based survivorship education and exergame equipment. For Aims 1 and 2, using an intention-to-treat framework, we will fit a series of linear mixed effects models with each of the outcome variables. For Aim 3, we will conduct our exploratory analyses in ml_mediation (STATA 15), which will compute direct and indirect effects for multi-level data. Type: Interventional Start Date: Aug 2020 |
Prenatal Behavioral Intervention to Prevent Maternal Cytomegalovirus (CMV) in Pregnancy
University of Alabama at Birmingham
Maternal Cytomegalovirus Infections
Cytomegalovirus Congenital
This study will evaluate whether a brief prenatal clinic-based cytomegalovirus (CMV)
risk-reduction behavioral intervention will prevent maternal CMV infections during
pregnancy in women. expand
This study will evaluate whether a brief prenatal clinic-based cytomegalovirus (CMV) risk-reduction behavioral intervention will prevent maternal CMV infections during pregnancy in women. Type: Interventional Start Date: Jan 2021 |
Phase II Panitumumab-IRDye800 in Head & Neck Cancer
University of Alabama at Birmingham
Head and Neck Cancer
The purpose of this study is to determine if panitumumab-IRDye800 is effective in
identifying cancer, compared to surrounding normal tissue, and the further characterize
the safety profile of this drug. expand
The purpose of this study is to determine if panitumumab-IRDye800 is effective in identifying cancer, compared to surrounding normal tissue, and the further characterize the safety profile of this drug. Type: Interventional Start Date: Apr 2021 |
Immunotherapy Before and After Surgery for Treatment of Recurrent or Progressive High Grade Glioma in...
Sabine Mueller, MD, PhD
Glioblastoma
Malignant Glioma
Recurrent Glioblastoma
Recurrent Malignant Glioma
Recurrent Grade III Glioma
This phase I trial studies the side effects of nivolumab before and after surgery in
treating children and young adults with high grade glioma that has come back (recurrent)
or is increasing in scope or severity (progressive). Immunotherapy with monoclonal
antibodies, such as nivolumab, may help the... expand
This phase I trial studies the side effects of nivolumab before and after surgery in treating children and young adults with high grade glioma that has come back (recurrent) or is increasing in scope or severity (progressive). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Type: Interventional Start Date: Oct 2020 |
A Trial of Transplanting Hepatitis C Kidneys Into Hepatitis C-Negative Kidney Recipients
University of Pennsylvania
End Stage Renal Disease
The Transplanting Hepatitis C Kidneys into Negative KidnEy Recipients [THINKER-NEXT]
study will include adult kidney transplant candidates without hepatitis C virus (HCV)
infection on the transplant waiting list who will consent to kidney transplantation from
a deceased donor infected with HCV, followed... expand
The Transplanting Hepatitis C Kidneys into Negative KidnEy Recipients [THINKER-NEXT] study will include adult kidney transplant candidates without hepatitis C virus (HCV) infection on the transplant waiting list who will consent to kidney transplantation from a deceased donor infected with HCV, followed by treatment with a direct acting antiviral. The one-year allograft function and one-year risk of CMV infection will be compared between THINKER-NEXT kidney transplant recipients and matched recipients who received hepatitis C uninfected kidney transplants (these patients are called Transplant Cohort). The survival rate of patients opting-in for offers of kidneys from HCV-viremic donors will be compared to the survival rate of matched comparators from the kidney transplant waitlist who did not consent to receive offers of a HCV-viremic kidney. Lastly, renal pathologic findings will be compared among HCV-viremic donors and HCV-negative comparator donors. Type: Interventional Start Date: Jun 2021 |
Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis
University of Alabama at Birmingham
Chronic Rhinosinusitis (Diagnosis)
The purpose of this pilot study is to explore wither ivacaftor in refractory CRS patients
will demonstrate safety and tolerability; restore CFTR-mediated Cl- secretions as
measured by EDSPD testing; produce detectable improvements in validated measures of CRS
including the SNOT-22 questionnaire, Lund-MacKay... expand
The purpose of this pilot study is to explore wither ivacaftor in refractory CRS patients will demonstrate safety and tolerability; restore CFTR-mediated Cl- secretions as measured by EDSPD testing; produce detectable improvements in validated measures of CRS including the SNOT-22 questionnaire, Lund-MacKay CT scan grading, and Lund-Kennedy endoscopic scores; and provide beneficial effects on readily measured markers of sinonasal inflammation and infection (IP-10, IL-8, and Pseudomonas CFUs). Type: Interventional Start Date: May 2019 |
Diet Interventions, by Race, Evaluated as Complementary Treatments for Pain
University of Alabama at Birmingham
Knee Osteoarthritis
Knee osteoarthritis (OA) is the most prevalent form of arthritis and race is a risk
factor for poor outcomes. Non-Hispanic Black individuals (NHB) report greater disability
and pain severity compared to Non-Hispanic Whites (NHW). These differences are reinforced
through social and biological mechanisms,... expand
Knee osteoarthritis (OA) is the most prevalent form of arthritis and race is a risk factor for poor outcomes. Non-Hispanic Black individuals (NHB) report greater disability and pain severity compared to Non-Hispanic Whites (NHW). These differences are reinforced through social and biological mechanisms, ultimately resulting in disparities in pain experience and associated quality of life. National efforts to reduce analgesic utilization highlight the critical need for safe, effective, and accessible alternatives for pain relief for underserved/at-risk populations. Low-carbohydrate diets (LCDs) reduce inflammation and pain independent of weight loss, indicating that diet interventions offer a non-pharmacological alternative. However, racial differences exist in metabolism that are rarely addressed in diet intervention studies. Therefore, a LCD may have greater pain-reducing effects in NHBs and provide an alternative treatment for pain. This will be the first study to examine the efficacy of these diets to reduce knee OA pain with an emphasis on race and interactions with biopsychosocial variables. Aim 1: To investigate the efficacy of the LCD to reduce pain and improve QOL. Hypothesis 1: The LCD group will show significantly greater reductions in: self-reported pain and evoked pain when compared to the USDA diet. Hypothesis 2: The LCD group will show greater improvements in: QOL, mood, and self-reported improvement. Hypothesis 3: Both diets will result in improved pain disability, severity, catastrophizing and pain-related fear; the LCD will outperform the USDA diet. Objective 2: To explore racial differences in diet effects and baseline measures. Hypothesis 1: NHBs will show greater improvements in pain, QOL, and mood. Hypothesis 2: NHBs will report greater food insecurity and less proximity to grocery stores. Hypothesis 3: Diet quality will be negatively associated with baseline pain sensitivity. Objective 3: To determine whether physiological variables contribute to diet effects or lack thereof. Hypothesis 1: Baseline physiological measures will predict: pain sensitivity and reductions in pain. NHBs will show greater inflammation at baseline than NHWs. Hypothesis 2: Change in physiological measures will be related to: change in pain, change in QOL, self-reported improvement and mood. NHWs will show greater reductions in inflammation and adiposity than NHBs. Type: Interventional Start Date: Feb 2023 |
CRISPR-Edited Allogeneic Anti-BCMA CAR-T Cell Therapy in Patients With Relapsed/Refractory Multiple Myeloma
Caribou Biosciences, Inc.
Relapsed/Refractory Multiple Myeloma
This is a Phase 1 study to evaluate the safety of CB-011 (the study treatment), an
allogeneic chimeric antigen receptor (CAR-T) cell therapy that targets the B cell
maturation antigen (BCMA), to determine the best dose of CB-011, and to assess the
effectiveness of CB-011 in treating multiple myeloma... expand
This is a Phase 1 study to evaluate the safety of CB-011 (the study treatment), an allogeneic chimeric antigen receptor (CAR-T) cell therapy that targets the B cell maturation antigen (BCMA), to determine the best dose of CB-011, and to assess the effectiveness of CB-011 in treating multiple myeloma that has come back (relapsed) or that is no longer responding to other treatment (refractory). Type: Interventional Start Date: Feb 2023 |
Pulsed Lavage in Implant-Based Breast Reconstruction
University of Alabama at Birmingham
Breast Reconstruction
To determine if there is any benefit to using pulsed lavage to wash out the mastectomy
pocket during breast reconstruction. Primary outcomes will include post-op complications
including surgical site infection (SSI), hematoma, seroma, and implant failure. expand
To determine if there is any benefit to using pulsed lavage to wash out the mastectomy pocket during breast reconstruction. Primary outcomes will include post-op complications including surgical site infection (SSI), hematoma, seroma, and implant failure. Type: Interventional Start Date: Mar 2024 |
An Investigator Initiated Open Label Study Evaluating the Efficacy and Tolerability of Oral Deucravacitinib...
University of Alabama at Birmingham
Nail Psoriasis
. An open label proof of concept study will be conducted to assess the efficacy and
safety of deucravactinib for treatment of nail psoriasis. Twenty adult patients with nail
psorasis and skin disease qualifying for a systemic agent per investigator will be
treated with deucravacitinib 6 mg daily.... expand
. An open label proof of concept study will be conducted to assess the efficacy and safety of deucravactinib for treatment of nail psoriasis. Twenty adult patients with nail psorasis and skin disease qualifying for a systemic agent per investigator will be treated with deucravacitinib 6 mg daily. Subjects will be assessed for a total of 48 weeks. Psoriasis assessments such as the modified Nail Psoriasis Severity Index will be conducted. Photos will be used to document nail involvement. Descriptive statistical analysis will be conducted at the conclusion of the study. Type: Interventional Start Date: Mar 2024 |
Comprehensive Preoperative Airway Grading
University of Alabama at Birmingham
Anesthesia Intubation Complication
Purpose of study: To contrast and compare the Mallampatti test to a comprehensive airway
grading test using a rigid 75-degree angle laryngoscope (CPAG) Study Hypothesis: The
investigators hypothesize that the CPAG will have greater sensitivity and specificity for
predicting difficulty laryngoscopy... expand
Purpose of study: To contrast and compare the Mallampatti test to a comprehensive airway grading test using a rigid 75-degree angle laryngoscope (CPAG) Study Hypothesis: The investigators hypothesize that the CPAG will have greater sensitivity and specificity for predicting difficulty laryngoscopy as compared to the Mallampati test. The investigators plan to test this hypothesis by comparing the correlation of (a) airway Mallampati airway grading (predicted airway difficulty) versus (b) CPAG view grading and Cormack Laryngoscopy assessment (observed airway difficulty). Type: Interventional Start Date: Nov 2022 |
Community Health Through Engagement and Environmental Renewal
University of Alabama at Birmingham
Family Relations
Blight
Community Health from Engagement and Environmental Renewal (CHEER) will leverage previous
Centers for Disease Control and Prevention (CDC) community engagement projects to reach
and intervene on a high need population. Disadvantage and poverty have long-term and
transgenerational adverse impacts on... expand
Community Health from Engagement and Environmental Renewal (CHEER) will leverage previous Centers for Disease Control and Prevention (CDC) community engagement projects to reach and intervene on a high need population. Disadvantage and poverty have long-term and transgenerational adverse impacts on social interaction and cohesion and residents' emotional and physical health. Mothers living and raising children in these conditions face multiple stressors without the community support previous generations relied on. Decades of research on American cities have connected the social, economic, and physical characteristics of neighborhoods with a lack of social cohesion, inability to maintain shared norms of acceptable behavior,and increases in health disparities and risky behaviors. Social cohesion and collective efficacy inversely associate with depression among youth. In a parallel manner, improved parenting practices and youth behavior directly associate with neighborhood social interactions and social cohesion. While these associations are suggestive, CHEER will directly test causal hypotheses at the neighborhood and family levels in a randomized control trial, that can significantly advance the evidence base for public health interventions: Family Youth Intervention (FYI) and an Environment: Social and Physical Intervention (ESPI) to increase social interaction, social cohesion, and collective efficacy and influence wellbeing of mothers and their youth. Type: Interventional Start Date: May 2021 |
- Previous
- Next