Dietary Prevention of Photodamage in Skin With Grapes
Purpose
To assess the effect of orally administered grape powder on the sunburn reaction in humans.
Condition
- Non-melanoma Skin Cancer
Eligibility
- Eligible Ages
- Between 18 Years and 99 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Patient age 18 and older - Patient able to understand requirements of the study and risks involved - Patient able to sign a consent form
Exclusion Criteria
- Patients Fitzpatrick IV-VI - A recent history of vitiligo, melasma, and other disorders of pigmentation with the exception of post inflammatory hyperpigmentation - A known history of photosensitivity disorders - A known history of melanoma or non-melanoma skin cancers - Those planning on going to the tanning parlors - Using any of the photosensitizing medication - A woman who is lactating, pregnant, or planning to become pregnant - Patient planning on exposing the irradiated or control areas to the sun
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- N/A
- Intervention Model
- Single Group Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
Arm | Description | Assigned Intervention |
---|---|---|
Other Reconstituted grape powder |
Open grape powder pouch and pour contents into volumetric measuring device. Add approximately 180 mL of water to container with grape powder. Stir for a minimum of 30 seconds and ingest. |
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More Details
- Status
- Completed
- Sponsor
- University of Alabama at Birmingham
Study Contact
Detailed Description
To determine whether oral grape powder will result in a reduction in biomarkers associated with basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs). Biomarkers taken from non-sun-exposed skin and UV-exposed skin before and after treatment will be compared. The ultimate goal of this study will be to generate new knowledge of the photoprotective effect of grape powder on UV exposure. The results may be employed as the basis for a larger clinical trial to evaluate the potential of grapes to prevent non-melanoma skin cancers (NMSCs) and sun damage.