Regulation of Inflammatory Genes in Psoriasis

Purpose

Psoriasis is a chronic and recurrent skin disorder characterized by marked inflammatory changes in the skin. An extensive cytokine network including generated by activated dendritic cells and T cells mediates the formation of psoriatic lesions. These immune-response parameters can be used as markers in the severity and management of the disease after further in-depth studies.

Conditions

  • Psoriasis
  • Inflammation

Eligibility

Eligible Ages
Between 19 Years and 99 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Clinical diagnosis of psoriasis - Must be age 19 or older. - Must be Fitzpatrick skin type I, II, III, IV, V, VI.

Exclusion Criteria

  • Subjects who do not have photosensitive disease and are not on photosensitizing medications. - Subjects with a history of keloids (who are more likely to develop hypertrophic scars following skin biopsy). - Subjects who have an allergy to local anesthetics, antibiotics and/or anticoagulants. - Subjects who are pregnant.

Study Design

Phase
Study Type
Observational
Observational Model
Case-Control
Time Perspective
Cross-Sectional

Recruiting Locations

The Kirklin Clinic
Birmingham, Alabama 35294
Contact:
Wendy Cantrell
205-502-9960
wcantrell@uabmc.edu

More Details

Status
Recruiting
Sponsor
University of Alabama at Birmingham

Study Contact