Pulmonary Vascular Hemodynamics Before and After Mitral Valve Procedures
Purpose
The objective of this proposal is to study circulating and echocardiographic markers of pulmonary vascular and right ventricular remodeling in patients with a WHO-2 diagnosis of pulmonary hypertension after mitral valve procedures. The investigators are proposing the study will be impactful for the early detection and prediction and of residual pulmonary hypertension (PH) that would otherwise be undetected and fatal with no curative treatment.
Condition
- Pulmonary Hypertension
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- >= 18 years/old
Exclusion Criteria
- Patients with ejection fraction (EF) < 35% - Patients with severe tricuspid valve regurgitation - Transplant patients - Patients scheduled for ventricular assist devices - Patients with a diagnosis of heart failure with preserved ejection fraction - Any aortic valvular disease
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Patients with moderate mitral valve disease, undergoing interventions | Patients with established WHO-2 diagnosis of PH undergoing open and interventional mitral valve procedures. |
|
| Patients undergoing mitral valve interventions without pulmonary hypertension | Patients with no PH undergoing open and interventional mitral valve procedures. This group will serve as a control. |
|
| Patients with precapillary pulmonary hypertension scheduled for right heart catheterization | Patients with established diagnosis of WHO-1-4 groups of PH undergoing right heart catheterization. This group will serve as a control. |
|
Recruiting Locations
Birmingham, Alabama 35294
More Details
- Status
- Recruiting
- Sponsor
- University of Alabama at Birmingham
Detailed Description
The investigators will enroll 3 groups: Group 1: Patients with established WHO-2 diagnosis of PH undergoing open and interventional mitral valve procedures. Group 2: Patients with no PH undergoing open and interventional mitral valve procedures. Group 3: Patients with established diagnosis of WHO-1-4 groups of PH undergoing right heart catheterization. Groups 2 and 3 will serve as controls. All procedures will be performed at the main UAB Hospital cardiac surgical operating rooms and at the cardiac angiographic suites. The investigators will collect a total of 3 blood samples; the first sample will be obtained on arterial cannulation before the initiation of the intervention, the second sample will be collected upon the end of the procedure prior to leaving the procedure room, and the third sample will be collected on the day of discharge from the hospital. A comprehensive echocardiogram at the 3 corresponding time points of the blood samples obtained; before, and after the intervention and before discharge.