Influence of Metabolic Syndrome on Endogenous Oxalate Synthesis

Purpose

This study aims to determine the daily rate of endogenous synthesis of oxalate using fasted urine collection and a low-oxalate controlled diet in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).

Conditions

  • MASLD
  • Metabolic Dysfunction-Associated Steatotic Liver Disease

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • age >18 years - History of MASLD, with liver fat content > 5% - Normal kidney function - Stable medication for at least 1 month for diabetes mellitus if any - Willingess to ingest fixed diets and stop dietary supplements for the study and come to UAB for visits

Exclusion Criteria

  • Age < 18 years - Inaccurate 24-hour urine collections - Liver fat content <5% - Liver cirrhosis - Evidence of other chronic liver disease, viral hepatitis - history of alcoholism within 2 years of enrollment - Contra-indication to Magnetic Resonance Imaging - Chronic kidney disease with estimated Glomerular Filtration rate < 60 ml/min/1.73m2 - Type 1 Diabetes Mellitus or treatment with insulin - Uncontrolled diabetes - Pregnancy, lactation or intention to be - Uncontrolled hypertension - Use of weight loss medication, SGLT2 inhibitors, GLP-1 receptor agonists, osteoporosis medication, chronic NSAID - History of gastric or intestinal surgery or resection that could potentially alter oxalate absorption - Chronic fat malabsorption - Use of immunosuppressive medications - Known immuno-compromised status - Active malignancy or treatment for malignanacy within the last 12 months

Study Design

Phase
N/A
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Primary Purpose
Basic Science
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Estimation of endogenous oxalate production 		Fasted hourly urine collections after equilibration on a low-oxalate diet
  • Dietary Supplement: Low-oxalate fixed diet
    Ingestion of a low-oxalate (< 60 mg/day) , normal calcium (800-1200 mg/d) eucaloric diet for 5 days

Recruiting Locations

University of Alabama at Birmingham
Birmingham, Alabama 35294
Contact:
Study Coordinator, MS
205-934-5712
kidneystone@uabmc.edu

More Details

Status
Recruiting
Sponsor
University of Alabama at Birmingham

Study Contact

Kyle D Wood, MD
2059968765
kylewood@uabmc.edu

Detailed Description

Urinary oxalate excretion is derived from both dietary sources and endogenous synthesis. This study will use a low-oxalate controlled diet, repeat fasted urine collections and 24-hr urine collections on a low-oxalate diet, to determine the daily rate of endogenous oxalate synthesis in individuals with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).