Induction of Cross-protective Antibodies for Serogroup 33 by Pneumococcal Conjugate Vaccines

Purpose

The goal of this study is to learn whether different types of vaccines to prevent bacterial infections are able to effectively create antibodies that defend against certain types of bacteria. We will give two different types of vaccine and evaluate the effectiveness of antibodies produced by each vaccine in killing bacteria.

Conditions

  • Vaccine
  • Pneumococcal Disease

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Healthy adult

Exclusion Criteria

  • No prior history of pneumococcal vaccination - No immunosuppressing medications or chronic diseases that affect immune function

Study Design

Phase
Phase 4
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Basic Science
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
PCV20 		Will receive PCV20
  • Biological: Pneumococcal Vaccine
    PCV
Experimental
PCV21 		Will receive PCV21
  • Biological: Pneumococcal Vaccine
    PCV

Recruiting Locations

University of Alabama at Birmingham
Birmingham, Alabama 35294
Contact:
LaFon, MD
2059343411
dlafon@uabmc.edu

More Details

Status
Recruiting
Sponsor
University of Alabama at Birmingham

Study Contact

David LaFon, MD
2059343411
dlafon@uabmc.edu