Purpose

The purpose of this study is to learn about using the imaging to make images of the lungs and nose with the long-term goal of the research leading to potential treatments and new therapies for patients with cystic fibrosis.

Conditions

Eligibility

Eligible Ages
Between 18 Years and 70 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Patients diagnosed with CF or healthy normal controls with no respiratory disease
  • Patients must be over the age of 18 but less than 70
  • Patient must be able to give informed consent

THE

Exclusion Criteria

  • Patients with recent respiratory infection requiring antibiotics or corticosteroids in the last 4 weeks (excluding routine perioperative antibiotics)
  • Patients with major sinus surgery that will alter the nasal anatomy and preclude imaging of the nares
  • Any condition that in the opinion of the investigator will alter the safety of pilot testing in the operating room
  • Female subjects who are pregnant

Study Design

Phase
Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
Notmal No lung Disease
Cystic Fibrosis cystic fibrosis Lung Disease
PCD Primary Ciliary Dyskinesia
COPD Chronic Obstructive Lung Disease

Recruiting Locations

University of Alabama at Birmingham
Birmingham, Alabama 35233
Contact:
Heather Hathorne, PhD
205-638-9568
hhathorne@peds.uab.edu

More Details

NCT ID
NCT03256773
Status
Recruiting
Sponsor
University of Alabama at Birmingham

Study Contact

Heather Hathorne, PhD
205-638-9568
hhathorne@peds.uab.edu

Detailed Description

Lung Disease is the predominate cause of morbidity and mortality in patients with cystic fibrosis (CF). A better understanding of the primary pathogenesis of CF is essential in order to reveal the features that may lead to the onset of progressive lung disease. Discerning the nature of the CF defect could resolve longstanding controversy and result in a new therapeutic opportunity that may address pathophysiology. Recently the investigators have developed an innovative technology, termed 1-µm resolution optical coherence tomography (µOCT), which enables real-time cross-sectional microscopy of the functional epithelial surface of living airways.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.