UAB - Center for Clinical and Translational Science

Determination of the Independent Effects of Beetroot Juice Components, Dietary Nitrate and Antioxidants, on Exercise Tolerance and Health Benefits in Individuals With Obesity

Purpose

The purpose of this study is to assess the effects of acute beetroot juice supplementation on exercise performance and cardiometabolic health in obese individuals with secondary cardiometabolic complications. Additionally, we will determine if the ergogenic health benefits of beetroot juice is due to the nitric oxide compound within the product, the antioxidant compound within the product, or a combination of the two compounds.

Conditions

Metabolic Disease
Obesity
Exercise

Eligibility

Eligible Ages: Between 18 Years and 40 Years
Eligible Genders: All
Accepts Healthy Volunteers: Yes

Inclusion Criteria

BMI ≥ 30 kg/m2 - Able to perform exercise testing on a cycle ergometer

Exclusion Criteria

Currently taking medications know to affect cardiovascular or respiratory function - Currently supplementing with an antioxidant compound - Current smoker - Currently taking antibiotics - Not willing to abstain from mouthwash use - Currently participating in regular physical activity

Study Design

Phase: N/A
Study Type: Interventional
Allocation: Randomized
Intervention Model: Crossover Assignment
Primary Purpose: Basic Science
Masking: Single (Participant)

Arm Groups

Arm	Description	Assigned Intervention
Experimental Beetroot Juice		Dietary Supplement: Beetroot Juice no Nitrate 70ml Concentrated Beetroot Juice with nitrate removed Dietary Supplement: Beetroot Juice 70ml Concentrated Beetroot Juice
Active Comparator Beetroot Juice no Nitrate		Dietary Supplement: Beetroot Juice no Nitrate 70ml Concentrated Beetroot Juice with nitrate removed
Active Comparator Sodium Nitrate		Dietary Supplement: Sodium Nitrate 70ml sodium nitrate, matched for nitrate concentration in Beetroot Juice arm
No Intervention Control

More Details

Status: Completed
Sponsor: University of Alabama at Birmingham

Study Contact

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.