Obesity and Endogenous Oxalate Synthesis
Purpose
The goal of this proposal is to determine the contribution and significance of obesity to urinary oxalate excretion and thus calcium oxalate kidney stone disease. Successful completion of the study will provide insight into the link between obesity and kidney stone disease and should identify future strategies to treat this disease.
Conditions
- Obesity
- Kidney Stone
Eligibility
- Eligible Ages
- Between 19 Years and 65 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Body Mass Index (BMI) < 30 - Calcium oxalate stone formers with passage or removal of a kidney stone containing > 50% calcium oxalate - Type 2 Diabetics with fasting glucose > 126 mg/dL or hemoglobin A1c greater than or equal to 6.5%
Exclusion Criteria
- Any disease that will affect the urinary excretion of oxalate, calcium or another ion that will compromise the interpretation of results. - Abnormal urine chemistries or blood metabolic profiles - A glomerular filtration rate (GFR) or estimated GFR < 60 mls/min - Pregnancy - Body Mass Index (BMI) > 32
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Non-Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Other
- Masking
- None (Open Label)
Arm Groups
Arm | Description | Assigned Intervention |
---|---|---|
Experimental Normal Individuals |
Normal individuals: no prior history of KS, no obesity, no diabetes |
|
Experimental Calcium Oxalate Kidney Stone Formers |
Those individuals that have a high propensity to form calcium oxalate kidney stones |
|
Experimental Type 2 Diabetes |
Those individuals that have been diagnosed with type 2 diabetes |
|
Experimental Type 2 diabetic kidney stone formers |
Those individuals that have been diagnosed with type 2 diabetes and kidney stones. |
|
More Details
- Status
- Active, not recruiting
- Sponsor
- University of Alabama at Birmingham