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Purpose

The purpose of this study is to evaluate mitochondrial function in white blood cells and platelets from healthy individuals following dietary oxalate intake.

Condition

Eligibility

Eligible Ages
Between 18 Years and 70 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Mentally competent adults who are able to read and comprehend the consent form, written in English - Male or Female - Age 18 to 70 years - Non-tobacco users - BMI between 19 and 27 - Willingness to abstain from vigorous exercise during study period - Normal blood comprehensive metabolic panel

Exclusion Criteria

  • Mentally incompetent adults who are unable to read or comprehend the consent form, written in English - Pregnant females - Active medical problems - History of kidney stones - Any medical disorder that could influence absorption or excretion of oxalate - BMI less than 19 or greater than 27 - Tobacco users - Current use of medications or dietary supplements

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Non-Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
3d Diet+Spinach Smoothie+Breakfast 		3 days of prepared meals with fasting on the final day. On final day, participants will return to study site and drink a prepared blended spinach smoothie and be provided a breakfast meal.
  • Dietary Supplement: Breakfast
    a prepared meal consisting of pastry and 2 cooked egg whites
  • Dietary Supplement: Spinach smoothie
    a prepared blended spinach smoothie, consisting of banana, avocado, orange juice, and spinach
Experimental
5d Diet+Spinach Smoothie+Breakfast 		5 days of prepared meals with fasting on the final day. On final day, participants will return to the study site and drink a prepared blended spinach smoothie and be provided a breakfast meal.
  • Dietary Supplement: Breakfast
    a prepared meal consisting of pastry and 2 cooked egg whites
  • Dietary Supplement: Spinach smoothie
    a prepared blended spinach smoothie, consisting of banana, avocado, orange juice, and spinach
Experimental
3d Diet+Kale Smoothie+Breakfast 		3 days of prepared meals with fasting on the final day. On the final day, participants will return to the study site and drink a prepared kale smoothie and be provided a breakfast meal.
  • Dietary Supplement: Breakfast
    a prepared meal consisting of pastry and 2 cooked egg whites
  • Dietary Supplement: Kale smoothie
    prepared blended kale smoothie, consisting of banana, avocado, orange juice, and kale
Experimental
3d Diet+V Spinach Smoothie+Breakfast 		3 days of prepared meals with fasting on the final day. On final day, participants will return to the study site and drink a prepared blended spinach smoothie with varying amounts of spinach and be provided a breakfast meal.
  • Dietary Supplement: Breakfast
    a prepared meal consisting of pastry and 2 cooked egg whites
  • Dietary Supplement: V spinach smoothie
    a prepared blended spinach smoothie, consisting of banana, avocado, orange juice, and a varying amount (low, medium, high) of spinach
Experimental
3d Diet+Blended Smoothie+Breakfast 		3 days of prepared meals with fasting on the final day. On final day, participants will return to the study site and drink a prepared blended smoothie and be provided a breakfast meal.
  • Dietary Supplement: Breakfast
    a prepared meal consisting of pastry and 2 cooked egg whites
  • Dietary Supplement: Blended smoothie
    a prepared blended smoothie, consisting of banana, avocado, and orange juice
Experimental
3d Diet+Breakfast 		3 days of prepared meals with fasting on the final day. On final day, participants will return to the study site and be provided a breakfast meal.
  • Dietary Supplement: Breakfast
    a prepared meal consisting of pastry and 2 cooked egg whites
Experimental
3d Diet+Sodium Oxalate Drink+Breakfast 		3 days of prepared meals with fasting on the final day. On final day, participants will return to the study site and drink a prepared sodium oxalate drink and be provided a breakfast meal.
  • Dietary Supplement: Breakfast
    a prepared meal consisting of pastry and 2 cooked egg whites
  • Dietary Supplement: Sodium oxalate drink
    a prepared sodium oxalate drink
Experimental
3d Diet+Spinach Smoothie+Breakfast w/ 24 Hr Urine 		3 days of prepared meals with fasting on the final day. On final day, participants will return to the study site and drink a blended spinach smoothie and be provided a breakfast meal.
  • Dietary Supplement: Breakfast
    a prepared meal consisting of pastry and 2 cooked egg whites
  • Dietary Supplement: Spinach smoothie
    a prepared blended spinach smoothie, consisting of banana, avocado, orange juice, and spinach

More Details

Status
Active, not recruiting
Sponsor
University of Alabama at Birmingham

Study Contact

Detailed Description

Inflammation and dietary oxalate have been shown to play an important role in the development of kidney stones. Oxalate is a small molecule found in plants and plant-derived food. Individuals that have high oxalate intake have an increased risk of developing kidney stones. The co-investigators have previously shown that healthy subjects that consume dietary oxalate have increased plasma and urine oxalate. White blood cells are essential for the immune response and rely on the mitochondria to carry out important cell functions. The Principal Investigator's current research shows that patients with calcium oxalate kidney stones have decreased mitochondrial function in their immune cells. Using the expertise of the investigators, this study will test whether oxalate has a direct effect on mitochondrial function in immune cells from healthy subjects. This information could help us understand the role of oxalate on the immune system during kidney stone pathogenesis.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.