Purpose

This is a Phase 1b open-label study to evaluate the safety and clinical activity of Zimberelimab (AB122) in biomarker-selected participants with advanced solid tumors.

Condition

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  1. Capable of giving signed informed consent. 2. Male or female participants ≥ 18 years of age at the time of screening. 3. Negative serum pregnancy test at screening and negative serum or urine pregnancy test every 3 months during the treatment period (women of childbearing potential only). 4. Pathologically confirmed tumor that is metastatic, advanced, or recurrent with progression for which no alternative or curative therapy exists. Tumors must be TMB-H or Strata Immune Signature positive. 5. Must have at least 1 measurable lesion per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. The measurable lesion must be outside of a radiation field if the participant received prior radiation. 6. Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1. 7. Prior chemotherapy or certain immune therapies or biologic agents must have been completed at least 4 weeks (28 days) before investigational product administration and all AEs have either returned to baseline or stabilized. 8. Previously treated brain or meningeal metastases with no evidence of progression by magnetic resonance imaging (MRI) for at least 4 weeks (28 days) prior to the first dose. 9. Immunosuppressive doses of systemic medications, such as corticosteroids or absorbed topical corticosteroids (doses > 10 mg/day prednisone or equivalent) must be discontinued at least 2 weeks (14 days) before investigational product administration. Physiologic doses of corticosteroids < 10 mg/day of prednisone or its equivalent may be permitted 10. Prior surgery that required general anesthesia or other major surgery as defined by the Investigator must be completed at least 4 weeks before investigational product administration 11. Negative tests for hepatitis B surface antigen, hepatitis C virus antibody (or hepatitis C qualitative ribonucleic acid [RNA; qualitative]), and human immunodeficiency virus (HIV)-1 and HIV-2 antibody at screening 12. Adequate organ and marrow function

Exclusion Criteria

  1. Use of any live attenuated vaccines against infectious diseases within 4 weeks (28 days) of initiation of investigational product. 2. Underlying medical conditions that, in the Investigator's or Sponsor's opinion, will make the administration of investigational product hazardous or obscure the interpretation of toxicity determination or AEs. 3. History of myocardial infarction within 6 months or history of arterial thromboembolic event within 3 months of the first dose of investigational agent. 4. Has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial. 5. Is pregnant or breastfeeding or expecting to conceive or father children within the projected duration of the study, starting with the pre-screening or screening visit through 90 days after the last dose of investigational product. 6. Any active or documented history of autoimmune disease or history of a syndrome that required systemic steroids or immunosuppressive medications. 7. Any acute gastrointestinal symptoms at the time of screening or admission. 8. Prior malignancy active within the previous year except for locally curable cancers that have been apparently cured. 9. Prior treatment with an anti-PD-L1, anti-PD-1, anti-CTLA-4, or other immune checkpoint inhibitor or agonist as monotherapy or in combination. 10. Prior treatment with temozolomide. 11. Use of other investigational drugs (drugs not marketed for any indication) within 28 days or at least 5 half-lives (whichever is longer) before investigational product administration.

Study Design

Phase
Phase 1
Study Type
Interventional
Allocation
Non-Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
TMB-H
Participants with a tumor biomarker status of TMB-H will receive Zimberelimab every 3 weeks.
  • Drug: Zimberelimab
    Zimberelimab is a fully human immunoglobulin G4 (IgG4) monoclonal antibody targeting human PD-1. Participants in each cohort will receive Zimberelimab intravenously Q3W. Treatment will continue until progressive disease, unacceptable toxicity, withdrawal of consent, or other reasons for which investigational product discontinuation occurs.
    Other names:
    • AB122
Experimental
Strata Immune Signature positive
Participants with a tumor biomarker status Strata Immune Signature positive will receive Zimberelimab every 3 weeks.
  • Drug: Zimberelimab
    Zimberelimab is a fully human immunoglobulin G4 (IgG4) monoclonal antibody targeting human PD-1. Participants in each cohort will receive Zimberelimab intravenously Q3W. Treatment will continue until progressive disease, unacceptable toxicity, withdrawal of consent, or other reasons for which investigational product discontinuation occurs.
    Other names:
    • AB122

Recruiting Locations

University of Alabama at Birmingham Comprehensive Cancer Center
Birmingham, Alabama 35233
Contact:
Betty Prescott
bprescott@uabmc.edu

More Details

Status
Recruiting
Sponsor
Arcus Biosciences, Inc.

Study Contact

Medical Director
510-694-6200
ClinicalTrialInquiry@arcusbio.com

Detailed Description

Zimberelimab every 3 weeks (Q3W) will be evaluated in molecularly defined patient populations as described by the StrataNGS test (to be performed outside of this study protocol). Participants with any advanced tumor type will be stratified evenly by tumor biomarker status as follows: TMB-H or Strata Immune Signature positive. Each cohort may enroll approximately 40 participants. Following completion of and/or discontinuation from investigational product and follow-up, all participants will be followed for survival.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.