Sleep-disordered Breathing in Infants With Myelomeningocele
This study aims to determine whether the risk for sleep-disordered breathing in infants with myelomeningocele (a severe form of spina bifida) differs among those who underwent fetal vs. postnatal surgery, and to examine the link between sleep-disordered breathing and neurodevelopment.
- Sleep-disordered Breathing
- Eligible Ages
- Under 2 Years
- Eligible Genders
- Accepts Healthy Volunteers
neonates with myelomeningocele who are cared for at a study center NICU are eligible to participate after myelomeningocele repair.
- born at <30 weeks gestation - congenital anomalies that would predispose to sleep-disordered breathing (e.g. micrognathia) - confirmed or suspected genetic syndromes that alter developmental outcomes
- Study Type
- Observational Model
- Time Perspective
|Prenatal Repair||This group received prenatal myelomeningocele repair.||
|Postnatal Repair||This group received postnatal myelomeningocele repair.||
- University of Michigan
Study ContactStephanie Clinical Research Project Manager
Myelomeningocele (MMC), the most severe form of spina bifida, is characterized by exposure of the spinal cord through a spinal defect. Sleep-disordered breathing (SDB) is common in children with MMC and is a risk factor for sudden death. Abnormal sleep physiology is likely multifactorial, related to MMC level, brainstem dysfunction, musculoskeletal factors, and pulmonary abnormalities. In infants, SDB may be treatable with oxygen, caffeine, or positive airway pressure. Yet, SDB screening is not routine, even in centers with specialized MMC programs. Evaluation of sleep in neonates who require intensive care is an emerging opportunity with potential for major impact on health and quality of life for affected children. As SDB and abnormal sleep are potentially treatable, early assessment and intervention could become an integral part of a multidisciplinary treatment strategy to optimize long-term medical and neurodevelopmental outcomes.