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Purpose

The investigators will attempt to develop a more accurate equation to estimate eGFR in pediatric and adult sickle cell patients

Conditions

Eligibility

Eligible Ages
Between 5 Years and 50 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • SCA patients (HbSS and SB0 thalassemia) - Age: 5.0-50.0 at enrollment

Exclusion Criteria

  • Recent SCA complication associated with hospitalization (within 30 days) or ED visit (within 14 days) - Current AKI defined as >0.3mg/g increase in SCr from prior visit - Known history of anaphylaxis with contrast agent or known pregnancy

Study Design

Phase
Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
Pediatric SCA We will develop a novel eGFR equation in 200 pediatric participants
  • Diagnostic Test: iohexol GFR
    We will perform mGFR in 400 SCA patients
Adult SCA We will develop a novel eGFR equation in 200 adult participants
  • Diagnostic Test: iohexol GFR
    We will perform mGFR in 400 SCA patients

Recruiting Locations

University of Alabama at Birmingham
Birmingham, Alabama 35223
Contact:
Jeffrey D Lebensburger, DO
205-638-9285
jlebensburger@peds.uab.edu

More Details

Status
Recruiting
Sponsor
University of Alabama at Birmingham

Study Contact

Jeffrey Lebensburger, DO, MSPH
205 638-9285
jlebensburger@peds.uab.edu

Detailed Description

200 pediatric and 200 adult SCA participants will undergo mGFR using iohexol at baseline and at one year. On the same day, participants will undergo clinical and laboratory variables important for developing an eGFR equation. From baseline data, the investigators will perform a training and validation cohort of biologically relevant predictor variables to develop a novel equation. Then the investigators will compare the novel SCA eGFR equation to the established eGFR equation. From one year data, the investigators will determine the longitudinal concordance between pediatric and adult novel and standard eGFR equations with mGFR and variables that may alter longitudinal inferences. In a subset of 30 adult participants, the investigators will also evaluate the correlation between mGFR using iohexol and a novel measure of mGFR that is more time efficient

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.