Print

Purpose

Mobility refers to a person's purposeful movement through the environment from one place to another and can be conceptualized as a continuum from bed bound (immobility) on one extreme to making excursions to distant locations on the other extreme. Primary open-angle glaucoma (POAG) is a chronic, progressive optic neuropathy that can lead to gradual loss of vision in the peripheral field and central vision. Older adults with POAG have an increased risk for motor vehicle collisions and falls. Moreover, existing studies suggest that patients with POAG exhibit more postural sway while standing as measured by a balance platform and also tend to walk more slowly than those who are normally sighted and free of ocular disease. While these disturbances likely influence mobility, there has been little research directly assessing the impact of POAG on mobility. This study will assess the impact of POAG on life space (one aspect of mobility) and will determine whether difficulties with life space are associated with difficulties experienced under conditions of dim lighting.

Condition

Eligibility

Eligible Ages
Between 18 Years and 100 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

(Patients): - Participants that are enrolled in the Early Detection of Glaucoma Progression using a Novel Individualized Approach (IRB-300000301) or in the African Descent and Glaucoma Evaluation (ADAGES) IV: Alterations of the Lamina Cribrosa in Progression (IRB-161115004).

Exclusion Criteria

(Patients): - Not being enrolled in one of the following two NIH-funded studies: 1. African Descent and Glaucoma Evaluation (ADAGES) IV: Alterations of the lamina cribrosa in progression (EY026574) or 2. Early detection of glaucoma progression using a novel individualized approach (EY025756) Inclusion Criteria (Controls): - No diagnosis of eye disease Exclusion Criteria (Controls): - Cognitive impairment that would preclude ability to take the tests

Study Design

Phase
Study Type
Observational
Observational Model
Case-Control
Time Perspective
Cross-Sectional

Arm Groups

ArmDescriptionAssigned Intervention
Primary Open-Angle Glaucoma Patients diagnosed with primary open-angle glaucoma.
  • Diagnostic Test: Life Space Questionnaire
    This 9-item questionnaire is interested in finding out how much a person gets out and about and the spatial extent of the person's typical life space, i.e., what is the usual range of places in which the person engages in activities within the designated time frame.
  • Diagnostic Test: Low Luminance Questionnaire
    This 32-item questionnaire is interested in finding out problems that involve vision under different lighting conditions or feelings that people have about your vision under different lighting conditions.
  • Diagnostic Test: Contrast sensitivity under dim illumination
    Participants will be presented with visual targets of different contrast under dim illumination and asked to report when they see the target.
  • Diagnostic Test: Visual field under dim illumination (MAIA)
    Sensitivity in the central visual area will be assessed under dim illumination
  • Diagnostic Test: Macular Pigment Optical Density (MPOD)
    Participants will be asked to look at a fixation target and the density of their macular pigment will be assessed.
  • Diagnostic Test: Dark Adaptation
    After adapting to a dark environment, participants will be exposed a bright flask of light. the time needed for them to recover their sensitivity will be measured.
Control Participants with healthy eyes.
  • Diagnostic Test: Life Space Questionnaire
    This 9-item questionnaire is interested in finding out how much a person gets out and about and the spatial extent of the person's typical life space, i.e., what is the usual range of places in which the person engages in activities within the designated time frame.
  • Diagnostic Test: Low Luminance Questionnaire
    This 32-item questionnaire is interested in finding out problems that involve vision under different lighting conditions or feelings that people have about your vision under different lighting conditions.
  • Diagnostic Test: Contrast sensitivity under dim illumination
    Participants will be presented with visual targets of different contrast under dim illumination and asked to report when they see the target.
  • Diagnostic Test: Visual field under dim illumination (MAIA)
    Sensitivity in the central visual area will be assessed under dim illumination
  • Diagnostic Test: Macular Pigment Optical Density (MPOD)
    Participants will be asked to look at a fixation target and the density of their macular pigment will be assessed.
  • Diagnostic Test: Dark Adaptation
    After adapting to a dark environment, participants will be exposed a bright flask of light. the time needed for them to recover their sensitivity will be measured.

Recruiting Locations

University of Alabama Birmingham
Birmingham, Alabama 35294-0001
Contact:
Lyne Racette, PhD
205-325-8673
lracette@uabmc.edu

More Details

Status
Recruiting
Sponsor
University of Alabama at Birmingham

Study Contact

Lyne Racette, PhD
205-325-8673
lracette@uabmc.edu

Detailed Description

Aim 1: To determine whether differences exist between people with healthy eyes and patients with POAG in seeing under dim illumination (Low Luminance Questionnaire) and to determine whether such differences are associated with life space. Aim 2: To determine whether differences exist between people with healthy eyes and patients with POAG in seeing under dim illumination (objective measures of visual function) and to determine whether such differences are associated with life space.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.