A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480 (BMS-986348) in Combination With Other Treatments in Participants With Relapsed or Refractory Multiple Myeloma
Purpose
The purpose of this study is to assess the safety, tolerability and preliminary effectiveness of CC-92480 (BMS-986348) in novel therapeutic combinations for the treatment of Relapsed or Refractory Multiple Myeloma (RRMM).
Condition
- Multiple Myeloma
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Relapsed or refractory multiple myeloma (MM) and must: 1. have documented disease progression during or after their last myeloma therapy 2. be refractory to, intolerant to, or not a candidate for available, established therapies known to provide clinical benefit in MM - Must have measurable disease - Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 or 1 - Agree to follow the CC-92480 Pregnancy Prevention Plan (PPP)
Exclusion Criteria
- Known active or history of central nervous system (CNS) involvement of MM - Plasma cell leukemia; Waldenstrom's macroglobulinemia; polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome; or clinically significant light-chain amyloidosis. - Impaired cardiac function or clinically significant cardiac disease - Previous SARS-CoV-2 infection within 14 days for asymptomatic or mild symptomatic infections or 28 days for severe/critical illness prior to Cycle 1 Day 1 (C1D1) - For Part 1: received prior therapy with CC-92480 - For Part 2: received prior therapy with CC-92480, tazemetostat, BMS-986158, or trametinib - Previously received allogeneic stem-cell transplant at any time or received autologous stem-cell transplant within 12 weeks of initiating study treatment - Received any of the following within 14 days prior to initiating study treatment: 1. Plasmapheresis 2. Major surgery 3. Radiation therapy other than local therapy for myeloma associated bone lesions 4. Use of any systemic anti-myeloma drug therapy - Used any investigational agents within 28 days or 5 half-lives (whichever is shorter) prior to initiating study treatment - COVID-19 vaccine within 14 days prior to C1D1 Other protocol-defined inclusion/exclusion criteria apply
Study Design
- Phase
- Phase 1/Phase 2
- Study Type
- Interventional
- Allocation
- Non-Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Part 1 Arm A: Dose Finding |
|
|
|
Experimental Part 1 Arm B: Dose Finding |
|
|
|
Experimental Part 1 Arm C: Dose Finding |
|
|
|
Active Comparator Part 2 Arm D: Dose Expansion |
|
|
|
Experimental Part 2 Arm E: Dose Expansion |
|
|
|
Experimental Part 2 Arm F: Dose Expansion |
|
|
|
Experimental Part 2 Arm G: Dose Expansion |
|
Recruiting Locations
UAB Comprehensive Cancer Center
Birmingham, Alabama 35249
Birmingham, Alabama 35249
Contact:
Luciano Costa, Site 0002
205-934-9695
Luciano Costa, Site 0002
205-934-9695
More Details
- Status
- Recruiting
- Sponsor
- Bristol-Myers Squibb
Study Contact
BMS Study Connect Contact Center www.BMSStudyConnect.com855-907-3286
Clinical.Trials@bms.com