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Purpose

The goal of this clinical trial is to test the effects of 10 weeks of exercise on overall brain health, reduction in blood pressure, and the number of blood vessels in the back of the eyes in patients with hypertension and have a body mass index ≥ 25 kg/m2. The main question[s] it aims to answer are: - To test the effect of moderate vs intensive exercise on Brain Care Score outcomes. - To ascertain the differential impact of moderate vs high intensity exercise in reducing hypertension and its downstream effects.

Conditions

Eligibility

Eligible Ages
Between 35 Years and 65 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • diagnosed with hypertension - have a body mass index ≥ 25 kg/m2 - are between the ages of 35-65 years old - access to a smart phone that allows installation of 2 two applications that record your workouts - pass a fitness evaluation.

Exclusion Criteria

  • do not have hypertension - weight over 300 lbs - unable to pass the fitness evaluation - BMI less than 25kg/m2

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Prevention
Masking
Single (Participant)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
High Intensity Interval Training (HIIT) exercise group, 		Participants will be asked to exercise independently 4 days/week for 10 weeks, following a high intensity interval training (HIIT) protocol.
  • Behavioral: Exercise Intervention to improve overall Brain Health
    During each exercise session, the participant will be assigned to the HIIT or MIT exercise group and asked to ride the stationary bicycle for approximately 30-40 minutes, while wearing the heart rate monitor and recording the session on their smart phone application. For each exercise session, the Polar Beat application will record the time in each of four intensity "zones". The participant will receive training on how to use the outlined schedule during the initial supervised training session.
Experimental
Moderate Intensity Training (MIT) exercise group 		Participants will be asked to exercise independently 4 days/week for 10 weeks, following a moderate intensity training (MIT) protocol.
  • Behavioral: Exercise Intervention to improve overall Brain Health
    During each exercise session, the participant will be assigned to the HIIT or MIT exercise group and asked to ride the stationary bicycle for approximately 30-40 minutes, while wearing the heart rate monitor and recording the session on their smart phone application. For each exercise session, the Polar Beat application will record the time in each of four intensity "zones". The participant will receive training on how to use the outlined schedule during the initial supervised training session.
Active Comparator
Control exercise group 		Participants will be advised to follow the American Heart Association (AHA) guidelines on exercise.
  • Behavioral: Exercise Intervention to improve overall Brain Health
    During each exercise session, the participant will be assigned to the HIIT or MIT exercise group and asked to ride the stationary bicycle for approximately 30-40 minutes, while wearing the heart rate monitor and recording the session on their smart phone application. For each exercise session, the Polar Beat application will record the time in each of four intensity "zones". The participant will receive training on how to use the outlined schedule during the initial supervised training session.

Recruiting Locations

UAB
Birmingham, Alabama 35294
Contact:
Pamela G. Bowen, PhD
205-934-2778
pbowen@uab.edu

More Details

Status
Recruiting
Sponsor
University of Alabama at Birmingham

Study Contact

Pamela G. Bowen, PhD
2054472343
pbowen@uab.edu

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.