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Purpose

To assess the effect of orally administered grape powder on the sunburn reaction in humans.

Condition

Eligibility

Eligible Ages
Between 18 Years and 99 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Patient age 18 and older - Patient able to understand requirements of the study and risks involved - Patient able to sign a consent form

Exclusion Criteria

  • Patients Fitzpatrick IV-VI - A recent history of vitiligo, melasma, and other disorders of pigmentation with the exception of post inflammatory hyperpigmentation - A known history of photosensitivity disorders - A known history of melanoma or non-melanoma skin cancers - Those planning on going to the tanning parlors - Using any of the photosensitizing medication - A woman who is lactating, pregnant, or planning to become pregnant - Patient planning on exposing the irradiated or control areas to the sun

Study Design

Phase
N/A
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Other
Reconstituted grape powder 		Open grape powder pouch and pour contents into volumetric measuring device. Add approximately 180 mL of water to container with grape powder. Stir for a minimum of 30 seconds and ingest.
  • Other: Reconstituted grape powder
    To prevent UV-induced skin cancers. Each subject's will have one arm exposed to 6 separate doses of UV (J/m2) [114, 217, 343, 500, 619, 848].
    Other names:
    • Grape powder

More Details

Status
Completed
Sponsor
University of Alabama at Birmingham

Study Contact

Detailed Description

To determine whether oral grape powder will result in a reduction in biomarkers associated with basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs). Biomarkers taken from non-sun-exposed skin and UV-exposed skin before and after treatment will be compared. The ultimate goal of this study will be to generate new knowledge of the photoprotective effect of grape powder on UV exposure. The results may be employed as the basis for a larger clinical trial to evaluate the potential of grapes to prevent non-melanoma skin cancers (NMSCs) and sun damage.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.