Influence of Metabolic Syndrome on Endogenous Oxalate Synthesis
Purpose
This study aims to determine the daily rate of endogenous synthesis of oxalate using fasted urine collection and a low-oxalate controlled diet in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
Conditions
- MASLD
- Metabolic Dysfunction-Associated Steatotic Liver Disease
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- age >18 years - History of MASLD, with liver fat content > 5% - Normal kidney function - Stable medication for at least 1 month for diabetes mellitus if any - Willingess to ingest fixed diets and stop dietary supplements for the study and come to UAB for visits
Exclusion Criteria
- Age < 18 years - Inaccurate 24-hour urine collections - Liver fat content <5% - Liver cirrhosis - Evidence of other chronic liver disease, viral hepatitis - history of alcoholism within 2 years of enrollment - Contra-indication to Magnetic Resonance Imaging - Chronic kidney disease with estimated Glomerular Filtration rate < 60 ml/min/1.73m2 - Type 1 Diabetes Mellitus or treatment with insulin - Uncontrolled diabetes - Pregnancy, lactation or intention to be - Uncontrolled hypertension - Use of weight loss medication, SGLT2 inhibitors, GLP-1 receptor agonists, osteoporosis medication, chronic NSAID - History of gastric or intestinal surgery or resection that could potentially alter oxalate absorption - Chronic fat malabsorption - Use of immunosuppressive medications - Known immuno-compromised status - Active malignancy or treatment for malignanacy within the last 12 months
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- N/A
- Intervention Model
- Single Group Assignment
- Primary Purpose
- Basic Science
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Estimation of endogenous oxalate production |
Fasted hourly urine collections after equilibration on a low-oxalate diet |
|
Recruiting Locations
University of Alabama at Birmingham
Birmingham, Alabama 35294
Birmingham, Alabama 35294
More Details
- Status
- Recruiting
- Sponsor
- University of Alabama at Birmingham
Detailed Description
Urinary oxalate excretion is derived from both dietary sources and endogenous synthesis. This study will use a low-oxalate controlled diet, repeat fasted urine collections and 24-hr urine collections on a low-oxalate diet, to determine the daily rate of endogenous oxalate synthesis in individuals with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).